메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
성연은 (가톨릭대학교) 기은영 ((학) 가톨릭대학교서울성모병원) 이연수 (가톨릭대학교) 허수영 (가톨릭대학교) 이아원 (가톨릭대학교) 박종섭 (가톨릭대학교)
저널정보
대한부인종양학회 Journal of Gynecologic Oncology Journal of Gynecologic Oncology Vol.27 No.6
발행연도
2016.1
수록면
1 - 10 (10page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Objective: Infection with high-risk genotypes of human papillomavirus (HR-HPV) is themajor cause of invasive cervical cancers. HPV-16 and HPV-18 are known to be responsiblefor two-thirds of all invasive cervical carcinomas, followed by HPV-45, -31, and -33. Current guidelines only differentiate HPV-16/18 (+) by recommending direct colposcopy fortreatment. We tried to evaluate whether there are differences in risk among 12 non-16/18 HRHPVgenotypes in this study. Methods: The pathology archive database records of 1,102 consecutive gynecologic patients,who had results for cervical cytology and histology and for HPV testing, as determined byHPV 9G DNA chip, were reviewed. Results: Among the 1,102 patients, 346 were non-16/18 HR-HPV (+) and 231 were HPV-16/18(+). We calculated the odds ratios for ≥cervical intraepithelial neoplasia 2 (CIN 2) of 14groups of each HR-HPV genotype compared with a group of HR-HPV (−) patients. Based onthe odds ratio of each genotype, we divided patients with non-16/18 HR-HPV genotypes (+)into two groups: HPV-31/33/35/45/52/58 (+) and HPV-39/51/56/59/66/68 (+). The age-adjustedodds ratios for ≥CIN 2 of the HPV-31/33/35/45/52/58 (+) and HPV-39/51/56/59/66/68 (+) groupscompared with a HR-HPV (−) group were 11.9 (95% CI, 7.6 to 18.8; p<0.001) and 2.4 (95% CI,1.4 to 4.3; p<0.001), respectively, while that of the HPV-16/18 (+) group was 18.1 (95% CI, 11.6to 28.3; p=0.003). Conclusion: The 12 non-16/18 HR-HPV genotypes can be further categorized (HPV-31/33/35/45/52/58 vs. HPV-39/51/56/59/66/68) by risk stratification. The HPV-31/33/35/45/52/58genotypes might need more aggressive action. Large scale clinical trials or cohort studies arenecessary to confirm our suggestion.

목차

등록된 정보가 없습니다.

참고문헌 (22)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0