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자료유형
학술저널
저자정보
저널정보
대한면역학회 Immune Network Immune Network Vol.16 No.4
발행연도
2016.8
수록면
211 - 218 (8page)

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초록· 키워드

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Due to the increasing prevalence and number of life-threatening cases, food allergy has emerged as a major health concern. The classic immune response seen during food allergy is allergen-specific IgE sensitization and hypersensitivity reactions to foods occur in the effector phase with often severe and deleterious outcomes. Recent research has advanced understanding of the immunological mechanisms occurring during the effector phase of allergic reactions to ingested food. Therefore, this review will not only cover the mucosal immune system of the gastrointestinal tract and the immunological mechanisms underlying IgE-mediated food allergy, but will also introduce cells recently identified to have a role in the hypersensitivity reaction to food allergens. These include IL-9 producing mucosal mast cells (MMC9s) and type 2 innate lymphoid cells (ILC2s). The involvement of these cell types in potentiating the type 2 immune response and developing the anaphylactic response to food allergens will be discussed. In addition, it has become apparent that there is a collaboration between these cells that contributes to an individual’s susceptibility to IgE-mediated food allergy.

목차

INTRODUCTION
THE IMMUNE SYSTEM IN THE GASTROINTESTINAL MUCOSAL
ADVERSE IMMUNE RESPONSE TO FOODS: FOOD ALLERGY/FOOD HYPERSENSITIVITY
CLASSICAL IMMUNE MECHANISMS OF IgE-MEDIATED FOOD ALLERGY
THE ROLE OF IL-25 AND IL-25 RESPONDING CELLS IN IgE-MEDIATED FOOD ALLERGY
THE ROLE OF IL-9 AND IL-9 PRODUCING MUCOSAL MAST CELLS IN IgE-MEDIATED FOOD ALLERGY
CONCLUSIONS
REFERENCES

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