지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.8
- 수록면
- 219 - 232 (14page)
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초록· 키워드
오류제보하기
Production of high affinity antibodies for antigens is a critical component for the immune system to fight off infectious pathogens. However, it could be detrimental to our body when the antigens that B cells recognize are of self-origin. Follicular helper T, or Tfh, cells are required for the generation of germinal center reactions, where high affinity antibody-producing B cells and memory B cells predominantly develop. As such, Tfh cells are considered as targets to prevent B cells from producing high affinity antibodies against self-antigens, when high affinity autoantibodies are responsible for immunopathologies in autoimmune disorders. This review article provides an overview of current understanding of Tfh cells and discusses it in the context of animal models of autoimmune diseases and allograft rejections for generation of novel therapeutic interventions.
목차
INTRODUCTION
MAIN
DISCUSSION
REFERENCES
참고문헌 (120)
참고문헌 신청
[단행본] - Murphy, K / 2012 / Janeway’s Immunobiology / Garland Science
[학술지(정기간행물)] - Kyewski, B / 2006 / A central role for central tolerance / Annu. Rev. Immunol 24 : 571 ~ 606
[학술지(정기간행물)] - Hardy, R. R. / 2001 / B cell development pathways / Annu. Rev. Immunol 19 : 595 ~ 621
[학술지(정기간행물)] - Sandel, P. C / 1999 / Negative selection of immature B cells by receptor editing or deletion is determined by site of antigen encounter / Immunity 10 : 289 ~ 299
[학술지(정기간행물)] - Goodnow, C. C / 1990 / The need for central and peripheral tolerance in the B cell repertoire / Science 248 : 1373 ~ 1379
[학술지(정기간행물)] - Kyewski, B / 2006 / A central role for central tolerance / Annu. Rev. Immunol 24 : 571 ~ 606
[학술지(정기간행물)] - Hardy, R. R. / 2001 / B cell development pathways / Annu. Rev. Immunol 19 : 595 ~ 621
[학술지(정기간행물)] - Sandel, P. C / 1999 / Negative selection of immature B cells by receptor editing or deletion is determined by site of antigen encounter / Immunity 10 : 289 ~ 299
[학술지(정기간행물)] - Goodnow, C. C / 1990 / The need for central and peripheral tolerance in the B cell repertoire / Science 248 : 1373 ~ 1379
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UCI(KEPA) : I410-ECN-0101-2017-517-000981461