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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 314 - 320 (7page)
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초록· 키워드
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Background: Angiotensin II type 1 receptor (AT1R) is responsible for cardiovascular effects mediated by angiotensin II. This study aimed to investigate the impact of antibodies directed against AT1R (anti-AT1R) in renal allograft rejection.
Methods: We evaluated 53 patients who had biopsy-proven rejection including antibody-mediated rejection (AMR) (N=22), T-cell-mediated rejection (TCMR) (N=29), and mixed AMR and TCMR (N=2). Donor specific HLA antibodies (DSA) and anti-AT1Rs were simultaneously determined.
Results: Anti-AT1Rs were detected in 9.4% (5/53) of rejection patients (one with acute AMR, two with chronic active AMR, one with acute TCMR, and one with mixed acute AMR & TCMR). HLA antibodies and DSA were detected in 75.5% (40/53) and 49.1% (26/53) of patients, respectively. There was no significant difference in transplant characteristics between anti-AT1R(+) and anti-AT1R(-) patients except for the association of HLA class-I DSA(+) and anti-AT1R(+). Four of five anti-AT1R(+) patients had DSA and were also found to have AMR. A single anti-AT1R(+)/DSA(-) patient developed acute TCMR. Detection rates of DSA, HLA antibodies, or anti-AT1R were not different between AMR and TCMR. However, DSA(+)/anti-AT1R(+) was more frequently found in AMR than in TCMR (P=0.036). Patients with anti-AT1R showed a greater tendency to develop high-grade rejection as Banff IIA/IIB or AMR.
Conclusions: The presence of anti-AT1R was significantly associated with HLA class-I DSA in renal allograft rejection patients. Both anti-AT1R and DSA positivity was associated with AMR in patients with renal allograft rejection.
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등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Amico P / 2008 / Incidence and prediction of early antibody-mediated rejection due to non-human leukocyte antigen-antibodies / Transplantation 85 : 1557 ~ 1563
Banasik M / 2014 / The influence of non-HLA antibodies directed against angiotensin II type 1 receptor (AT1R) on early renal transplant outcomes / Transpl Int 27 : 1029 ~ 103
Chung BH / 2014 / Clinical impact of the baseline donor-specific anti-human leukocyte antigen antibody measured by Luminex single antigen assay in living donor kidney transpl
Cox ST / 2011 / Major histocompatibility complex class I-related chain A allele mismatching, antibodies, and rejection in renal transplantation / Hum Immunol 72 : 827 ~ 834
Dragun D / 2005 / Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection / N Engl J Med 352 : 558 ~ 569
Banasik M / 2014 / The influence of non-HLA antibodies directed against angiotensin II type 1 receptor (AT1R) on early renal transplant outcomes / Transpl Int 27 : 1029 ~ 103
Chung BH / 2014 / Clinical impact of the baseline donor-specific anti-human leukocyte antigen antibody measured by Luminex single antigen assay in living donor kidney transpl
Cox ST / 2011 / Major histocompatibility complex class I-related chain A allele mismatching, antibodies, and rejection in renal transplantation / Hum Immunol 72 : 827 ~ 834
Dragun D / 2005 / Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection / N Engl J Med 352 : 558 ~ 569
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