지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,638 - 1,642 (5page)
이용수
초록· 키워드
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Purpose: Recently, bortezomib has been used to treat antibody-mediated rejection (AMR) refractory to conventional treatmentsuch as plasmapheresis, intravenous immunoglobulin, and rituximab. The authors aimed to describe their experiences whenbortezomib was used to treat refractory AMR.
Materials and Methods: Eleven refractory AMR episodes treated with bortezomib were included in this study. The patients receivedone or two cycles of bortezomib (1.3 mg/m2) on days 1, 4, 8, and 11.
Results: Bortezomib effectively reduced antibodies against various targets, including human leukocyte antigen (HLA) class I andII, ABO blood group antigen, and angiotensin II type 1 receptor. Antibodies were depleted or reduced significantly in eight AMRepisodes. Overall, there was a significant improvement in the mean estimated glomerular filtration rate (eGFR) at 3 months aftertherapy (36.91±22.15 mL/min/1.73 m2) versus eGFR at time of AMR diagnosis (17.00±9.25 mL/min/1.73 m2; p=0.007). All six early-onset AMR episodes (within 6 months post-transplantation) showed full recovery of allograft function. Additionally, three ofthe five late-onset AMR episodes (>6 months post-transplantation) showed improved allograft function.
Conclusion: Anti-humoral treatment based on bortezomib might be an effective strategy against refractory AMR caused by varioustypes of antibodies. Notably, this treatment could be more effective in early-onset AMR than in late-onset AMR.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Djamali A / 2014 / Diagnosis and management of antibody-mediated rejection:current status and novel approaches / Am J Transplant 14 : 255 ~ 271
Ejaz NS / 2014 / Review of bortezomib treatment of antibody-mediated rejection in renal transplantation / Antioxid Redox Signal 21 : 2401 ~ 2418
Gertz MA / 2014 / Immunoglobulin light chain amyloidosis: 2014 update on diagnosis, prognosis, and treatment / Am J Hematol 89 : 1132 ~ 1140
Gloor JM / 2007 / Transplant glomerulopathy: subclinical incidence and association with alloantibody / Am J Transplant 7 : 2124 ~ 2132
Gupta G / 2014 / Late antibody-mediated rejection in renal allografts:outcome after conventional and novel therapies / Transplantation 97 : 1240 ~ 1246
Ejaz NS / 2014 / Review of bortezomib treatment of antibody-mediated rejection in renal transplantation / Antioxid Redox Signal 21 : 2401 ~ 2418
Gertz MA / 2014 / Immunoglobulin light chain amyloidosis: 2014 update on diagnosis, prognosis, and treatment / Am J Hematol 89 : 1132 ~ 1140
Gloor JM / 2007 / Transplant glomerulopathy: subclinical incidence and association with alloantibody / Am J Transplant 7 : 2124 ~ 2132
Gupta G / 2014 / Late antibody-mediated rejection in renal allografts:outcome after conventional and novel therapies / Transplantation 97 : 1240 ~ 1246
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