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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1 - 13 (13page)
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Background: The association of de novo donor-specific anti-human leukocyte antigens (HLA) antibodies (DSA) and development of antibody-mediated rejection (AMR) in kidney transplant recipients (KTRs) is still undetermined. Methods: We prospectively screened de novo DSA in 167 KTRs during 32 months after kidney transplantation (KT). Timing of DSA detection was at 3, 6, and 12 months post-transplant and annually thereafter and when clinically indicated. DSA levels were determined by Luminex assays and expressed as mean fluorescence intensity (MFI). We evaluated the incidence, characteristics of DSA, and association between DSA and tacrolimus trough levels or AMR. Results: De novo DSA developed in 16 KTRs (9.6%) and acute AMR occurred more commonly in KTRs with de novo DSA compared to KTRs without de novo DSA (18.8% vs. 0%, P < 0.001). All de novo DSA were against class II antigens. The mean number of DSA was 1.8 ± 1.2 and the average MFI of DSA was 7,399 ± 5,470. Tacrolimus trough level during the first 0–2 months after KT was an independent predictor of DSA development (hazard ratio, 0.70; 95% confidence interval, 0.50–0.99; P = 0.043). No differences were found in the number of DSA, average MFI of DSA, and tacrolimus levels during the first year between de novo DSA-positive KTRs with AMR and those without AMR. Conclusion: The results of our study suggest that monitoring of DSA and maintaining proper tacrolimus levels are essential to prevent AMR during the initial period after KT.
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등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Loupy A / 2012 / The impact of donor-specific anti-HLA antibodies on late kidney allograft failure / Nat Rev Nephrol 8(6):348~357
Einecke G / 2009 / Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure / Am J Transplant 9(11):2520~2531
Heilman RL / 2014 / De novo donor-specific human leukocyte antigen antibodies early after kidney transplantation / Transplantation 98(12):1310~1315
Campos EF / 2006 / Post-transplant anti-HLA class II antibodies as risk factor for late kidney allograft failure / Am J Transplant 6(10):2316~2320
Mohan S / 2012 / Donor-specific antibodies adversely affect kidney allograft outcomes / J Am Soc Nephrol 23(12):2061~2071
Einecke G / 2009 / Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure / Am J Transplant 9(11):2520~2531
Heilman RL / 2014 / De novo donor-specific human leukocyte antigen antibodies early after kidney transplantation / Transplantation 98(12):1310~1315
Campos EF / 2006 / Post-transplant anti-HLA class II antibodies as risk factor for late kidney allograft failure / Am J Transplant 6(10):2316~2320
Mohan S / 2012 / Donor-specific antibodies adversely affect kidney allograft outcomes / J Am Soc Nephrol 23(12):2061~2071
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