지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 606 - 613 (8page)
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초록· 키워드
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Purpose: Data on the distribution and impact of panel reactive antibodies (PRA) and donor specific antibodies (DSA) before lung transplantation in Asia, especially multi-center-based data, are limited. This study evaluated the prevalence of and effects of PRA and DSA levels before lung transplantations on outcomes in Korean patients using nationwide multicenter registry data. Materials and Methods: This study included 103 patients who received a lung transplant at five tertiary hospitals in South Korea between March 2015 and December 2017. Mortality, primary graft dysfunction (PGD), and bronchiolitis obliterans syndrome (BOS) were evaluated. Results: Sixteen patients had class I and/or class II PRAs exceeding 50%. Ten patients (9.7%) had DSAs with a mean fluorescence intensity (MFI) higher than 1000, six of whom had antibodies with a high MFI (≥2000). DSAs with high MFIs were more frequently observed in patients with high-grade PGD (≥2) than in those with no or low-grade (≤1) PGD. In the 47 patients who survived for longer than 9 months and were evaluated for BOS after the transplant, BOS was not related to DSA or PRA levels. One-year mortality was more strongly related to PRA class I exceeding 50% than that under 50% (0% vs. 16.7%, p=0.007). Conclusion: Preoperative DSAs and PRAs are related to worse outcomes after lung transplantation. DSAs and PRAs should be considered when selecting lung transplant recipients, and recipients who have preoperative DSAs with high MFI values and high PRA levels should be monitored closely after lung transplantation.
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참고문헌 (35)
참고문헌 신청
Ravindranath MH / 2017 / The humoral theory of transplantation / J Immunol Res 2017:5935123
Hadjiliadis D / 2005 / Pre-transplant panel reactive antibody in lung transplant recipients is associated with significantly worse post-transplant survival in a multicenter study / J Heart Lung Transplant 24:S249~S254
Shah AS / 2008 / Pretransplant panel reactive antibodies in human lung transplantation : an analysis of over 10, 000 patients / Ann Thorac Surg 85:1919~1924
Hayes D Jr / 2016 / Pre-transplant panel reactive antibody and survival in adult cystic fibrosis patients after lung transplantation / Lung 194:429~435
Costa J / 2017 / Long-term outcomes and management of lung transplant recipients / Best Pract Res Clin Anaesthesiol 31:285~297
Hadjiliadis D / 2005 / Pre-transplant panel reactive antibody in lung transplant recipients is associated with significantly worse post-transplant survival in a multicenter study / J Heart Lung Transplant 24:S249~S254
Shah AS / 2008 / Pretransplant panel reactive antibodies in human lung transplantation : an analysis of over 10, 000 patients / Ann Thorac Surg 85:1919~1924
Hayes D Jr / 2016 / Pre-transplant panel reactive antibody and survival in adult cystic fibrosis patients after lung transplantation / Lung 194:429~435
Costa J / 2017 / Long-term outcomes and management of lung transplant recipients / Best Pract Res Clin Anaesthesiol 31:285~297
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