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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.21 No.3
- 발행연도
- 2016.9
- 수록면
- 197 - 201 (5page)
이용수
초록· 키워드
오류제보하기
Helicobacter pylori infection is associated with an increased risk of developing upper gastrointestinal tract diseases. However, treatment failure is a major cause of concern mainly due to possible recurrence of infection, the side effects, and resistance to antibiotics. The aim of this study was to investigate the activities of Centella asiatica leaf extract (CAE) against H. pylori both in vitro and in vivo. The minimum inhibitory concentrations (MICs) against 55 clinically isolated strains of H. pylori were tested using an agar dilution method. The MICs of CAE ranged from 0.125 mg/mL to 8 mg/mL, effectiveness in inhibiting H. pylori growth was 2 mg/mL. The anti-H. pylori effects of CAE in vivo were also examined in H. pylori-infected C57BL/6 mice. CAE was orally administrated once daily for 3 weeks at doses of 50 mg/kg and 250 mg/kg. CAE at the 50 mg/kg dose significantly reduced H. pylori colonization in mice gastric mucosa. Our study provides novel insights into the therapeutic effects of CAE against H. pylori infection, and it suggests that CAE may be useful as an alternative therapy.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (32)
참고문헌 신청
[학술지(정기간행물)] - Parsonnet J / 1991 / Helicobacter pylori infection and the risk of gastric carcinoma / N Engl J Med 325 : 1127 ~ 1131
[학술지(정기간행물)] - Nomura A / 1991 / Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii / N Engl J Med 325 : 1132 ~ 1136
[학술지(정기간행물)] - Nomura A / 1994 / Helicobacter pylori infection and the risk for duodenal and gastric ulceration / Ann Intern Med 120 : 977 ~ 981
[학술지(정기간행물)] - Schöttker B / 2012 / Helicobacter pylori infection is strongly associated with gastric and duodenal ulcers in a large prospective study / Clin Gastroenterol Hepatol 10 : 487 ~ 493
[학술지(정기간행물)] - Fuccio L / 2009 / Meta-analysis : can Helicobacter pylori eradication treatment reduce the risk for gastric cancer? / Ann Intern Med 151 : 121 ~ 128
[학술지(정기간행물)] - Nomura A / 1991 / Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii / N Engl J Med 325 : 1132 ~ 1136
[학술지(정기간행물)] - Nomura A / 1994 / Helicobacter pylori infection and the risk for duodenal and gastric ulceration / Ann Intern Med 120 : 977 ~ 981
[학술지(정기간행물)] - Schöttker B / 2012 / Helicobacter pylori infection is strongly associated with gastric and duodenal ulcers in a large prospective study / Clin Gastroenterol Hepatol 10 : 487 ~ 493
[학술지(정기간행물)] - Fuccio L / 2009 / Meta-analysis : can Helicobacter pylori eradication treatment reduce the risk for gastric cancer? / Ann Intern Med 151 : 121 ~ 128
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UCI(KEPA) : I410-ECN-0101-2017-594-001391864