지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.11
- 수록면
- 15 - 22 (8page)
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초록· 키워드
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Background: Arsenic is a carcinogenic heavy metal that has a species-dependent health effects and abandoned metal mines are a source of significant arsenic exposure. Therefore, the aims of this study were to analyze urinary arsenic species and their concentration in residents living near abandoned metal mines and to monitor the environmental health effects of abandoned metal mines in Korea.
Methods: This study was performed in 2014 to assess urinary arsenic excretion patterns of residents living near abandoned metal mines in South Korea. Demographic data such as gender, age, mine working history, period of residency, dietary patterns, smoking and alcohol use, and type of potable water consumed were obtaining using a questionnaire. Informed consent was also obtained from all study subjects (n = 119). Urinary arsenic species were quantified using high performance liquid chromatography (HPLC) and inductively coupled plasma mass spectrometry (ICP/MS).
Results: The geometric mean of urinary arsenic (sum of dimethylarsinic acid, monomethylarsonic acid, As<SUP>3+</SUP>, and As<SUP>5+</SUP>) concentration was determined to be 131.98 μg/L (geometric mean; 95% CI, 116.72–149.23) while urinary inorganic arsenic (As<SUP>3+</SUP> and As<SUP>5+</SUP>) concentration was 0.81 μg/L (95% CI, 0.53–1.23). 66.3% (n = 79) and 21.8% (n = 26) of these samples exceeded ATSDR reference values for urinary arsenic (>100 μg/L) and inorganic arsenic (>10 μg/L), respectively. Mean urinary arsenic concentrations (geometric mean, GM) were higher in women then in men, and increased with age. Of the five regions evaluated, while four regions had inorganic arsenic concentrations less than 0. 40 μg/L, one region showed a significantly higher concentration (GM 15.48 μg/L; 95% CI, 7.51–31.91) which investigates further studies to identify etiological factors.
Conclusion: We propose that the observed elevation in urinary arsenic concentration in residents living near abandoned metal mines may be due to environmental contamination from the abandoned metal mine. Trial registration: Not Applicable (We do not have health care intervention on human participants).
Methods: This study was performed in 2014 to assess urinary arsenic excretion patterns of residents living near abandoned metal mines in South Korea. Demographic data such as gender, age, mine working history, period of residency, dietary patterns, smoking and alcohol use, and type of potable water consumed were obtaining using a questionnaire. Informed consent was also obtained from all study subjects (n = 119). Urinary arsenic species were quantified using high performance liquid chromatography (HPLC) and inductively coupled plasma mass spectrometry (ICP/MS).
Results: The geometric mean of urinary arsenic (sum of dimethylarsinic acid, monomethylarsonic acid, As<SUP>3+</SUP>, and As<SUP>5+</SUP>) concentration was determined to be 131.98 μg/L (geometric mean; 95% CI, 116.72–149.23) while urinary inorganic arsenic (As<SUP>3+</SUP> and As<SUP>5+</SUP>) concentration was 0.81 μg/L (95% CI, 0.53–1.23). 66.3% (n = 79) and 21.8% (n = 26) of these samples exceeded ATSDR reference values for urinary arsenic (>100 μg/L) and inorganic arsenic (>10 μg/L), respectively. Mean urinary arsenic concentrations (geometric mean, GM) were higher in women then in men, and increased with age. Of the five regions evaluated, while four regions had inorganic arsenic concentrations less than 0. 40 μg/L, one region showed a significantly higher concentration (GM 15.48 μg/L; 95% CI, 7.51–31.91) which investigates further studies to identify etiological factors.
Conclusion: We propose that the observed elevation in urinary arsenic concentration in residents living near abandoned metal mines may be due to environmental contamination from the abandoned metal mine. Trial registration: Not Applicable (We do not have health care intervention on human participants).
목차
Abstract
Background
Methods
Results
Conclusion
References
참고문헌 (30)
참고문헌 신청
Chen CJ / 1992 / Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water / Br J Cancer 66(5):888~892
Karagas MR / 2015 / Drinking water arsenic contamination, skin lesions, and malignancies : a systematic review of the global evidence / Curr Environ Health Rep 2(1):52~68
Roy RV / 2015 / Epigenetic targets of arsenic : emphasis on epigenetic modifications during carcinogenesis / J Environ Pathol Toxicol Oncol 34(1):63~84
Mazumder DN / 2008 / Chronic arsenic toxicity and human health / Indian J Med Res 128(4):436~447
Soleo L / 2008 / Significance of urinary arsenic speciation in assessment of seafood ingestion as the main source of organic and inorganic arsenic in a population resident near a coastal area / Chemosphere 73(3):291~299
Karagas MR / 2015 / Drinking water arsenic contamination, skin lesions, and malignancies : a systematic review of the global evidence / Curr Environ Health Rep 2(1):52~68
Roy RV / 2015 / Epigenetic targets of arsenic : emphasis on epigenetic modifications during carcinogenesis / J Environ Pathol Toxicol Oncol 34(1):63~84
Mazumder DN / 2008 / Chronic arsenic toxicity and human health / Indian J Med Res 128(4):436~447
Soleo L / 2008 / Significance of urinary arsenic speciation in assessment of seafood ingestion as the main source of organic and inorganic arsenic in a population resident near a coastal area / Chemosphere 73(3):291~299
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UCI(KEPA) : I410-ECN-0101-2017-517-001895597