지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 373 - 380 (8page)
이용수
초록· 키워드
오류제보하기
Peroxiredoxin-3 (Prdx3) is a mitochondrial protein of the thioredoxin family of antioxidant peroxidases and is the principal peroxidase responsible for metabolizing mitochondrial hydrogen peroxide. Recent reports have shown that mitochondrial reactive oxygen species (mROS) contribute to macrophage-mediated bactericidal activity in response to Toll-like receptors. Herein, we investigated the functional effect of Prdx3 in bactericidal activity. The mitochondrial localization of Prdx3 in HEK293T cells was confirmed by cell fractionation and confocal microscopy analyses. To investigate the functional role of Prdx3 in bactericidal activity, Prdx3-knockdown (Prdx3<SUP>KD</SUP>) THP-1 cells were generated. The mROS levels in Prdx3<SUP>KD</SUP> THP-1 cells were significantly higher than those in control THP-1 cells. Moreover, the mROS levels were markedly increased in response to lipopolysaccharide. Notably, the Salmonella enterica serovar Typhimurium infection assay revealed that the Prdx3<SUP>KD</SUP> THP-1 cells were significantly resistant to S. Typhimurium infection, as compared with control THP-1 cells. Taken together, these results indicate that Prdx3 is functionally important in bactericidal activity through the regulation of mROS.
목차
INTRODUCTION
Materials and Methods
Results and Discussion
REFERENCES
참고문헌 (30)
참고문헌 신청
[학술지(정기간행물)] - Murphy, M. P / 2009 / How mitochondria produce reactive oxygen species / Biochem. J 417 : 1 ~ 13
[학술지(정기간행물)] - Mailloux, R. J / 2015 / Teaching the fundamentals of electron transfer reactions in mitochondria and the production and detection of reactive oxygen species / Redox. Biol 4 : 381 ~ 398
[학술지(정기간행물)] - Mailloux, R. J / 2014 / Redox regulation of mitochondrial function with emphasis on cysteine oxidation reactions / Redox. Biol 2 : 123 ~ 139
[학술지(정기간행물)] - Liu, Y / 2002 / Generation of reactive oxygen species by the mitochondrial electron transport chain / J. Neurochem 80 : 780 ~ 787
[학술지(정기간행물)] - Titov, D. V / 2016 / Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio / Science 352 : 231 ~ 235
[학술지(정기간행물)] - Mailloux, R. J / 2015 / Teaching the fundamentals of electron transfer reactions in mitochondria and the production and detection of reactive oxygen species / Redox. Biol 4 : 381 ~ 398
[학술지(정기간행물)] - Mailloux, R. J / 2014 / Redox regulation of mitochondrial function with emphasis on cysteine oxidation reactions / Redox. Biol 2 : 123 ~ 139
[학술지(정기간행물)] - Liu, Y / 2002 / Generation of reactive oxygen species by the mitochondrial electron transport chain / J. Neurochem 80 : 780 ~ 787
[학술지(정기간행물)] - Titov, D. V / 2016 / Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio / Science 352 : 231 ~ 235
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Prdx1 (peroxiredoxin 1) deficiency reduces cholesterol efflux via impaired macrophage lipophagic flux
한국실험동물학회 학술발표대회 논문집
2017 .08
-
Oxidative Stress Modulates the Expression Pattern of Peroxiredoxin-6 in Peripheral Blood Mononuclear Cells of Asthmatic Patients and Bronchial Epithelial Cells
Allergy, Asthma & Immunology Research
2020 .01
-
Effects of Peroxy Acid Structured Oxygen-Based Bactericidal Agent on Multidrug-Resistant Bacteria
환경독성보건학회 심포지엄 및 학술대회
2024 .10
-
Change of Peroxiredoxin-5 Expression by Curcumin Treatment in Focal Cerebral Ischemia
한국실험동물학회 학술발표대회 논문집
2016 .08
-
A Simple, Reproducible, Inexpensive, Yet Old-Fashioned Method for Determining Phagocytic and Bactericidal Activities of Macrophages
Yonsei Medical Journal
2016 .01
-
Dissociation of mitochondrial reactive oxygen species and skeletal muscle insulin resistance in vivo mouse models
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Peroxiredoxin 5 attenuates non-alcoholic fatty liver disease regulating oxidative stress and AMP-activated protein kinase signaling in obese mouse models
한국실험동물학회 학술발표대회 논문집
2020 .07
-
Role of the mitochondrial stress response in human cancer progression
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Plasma Nuclear Factor Kappa B and Serum Peroxiredoxin 3 in Early Diagnosis of Hepatocellular Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
The deletion of Peroxiredoxin 5 aggravates iron overload-induced neuronal death via ER-mediated mitochondrial fission in mouse hippocampus
한국실험동물학회 학술발표대회 논문집
2020 .07
-
The Pro-apoptotic Effects of S100A8 and S100A9 in Human Monocytic Leukemia Cells, THP-1
대한의생명과학회지
2018 .06
-
Mitochondrial Mechanisms in Diabetic Cardiomyopathy
Diabetes and Metabolism Journal
2020 .01
-
Restoring mitochondrial dynamics in neuronal health through photobiomodulation
MEDICAL LASERS
2024 .09
-
Optimized applications of ozonated water as an effective disinfectant for Staphylococcus aureus clearance in an abattoir setting
예방수의학회지
2017 .06
-
Bactericidal effects of chlorine dioxide gas against E. coli and S. Typhimurium in vitro
예방수의학회지
2017 .12
-
사람 호흡기 상피세포에서 Peroxiredoxin 2에 의한 Lipopolysaccharide에 유도된점액 발현과 Reactive Oxygen Species 생성의 억제
대한이비인후-두경부외과학회지
2021 .12
-
The Role of Peroxiredoxin Family in Cancer Signaling
대한암예방학회지
2019 .01
-
당귀로부터 정제한 Decursin의 인간 급성 단핵구성 백혈병 세포(THP-1 cells)의 세포 독성 및 Apoptosis에 미치는 영향
생약학회지(Korean Journal of Pharmacognosy)
2016 .09
-
Retinoic acid regulates thioredoxin and peroxiredoxin-2 in ischemic-injured cerebral cortex
한국실험동물학회 학술발표대회 논문집
2021 .01
-
The antipsychotic drug pimozide inhibits the human prostate cancer cells through the generation of reactive oxygen species
한국실험동물학회 학술발표대회 논문집
2019 .07
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2017-517-001849015