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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.2
- 수록면
- 53 - 61 (9page)
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Objectives：Patients with mild cognitive impairment(MCI) are known to be commonly accompanied by depression. The aim of this study was to investigate the characteristics of depressive symptoms in patient with amnestic MCI(aMCI).
Methods：Three hundred and thirty two individuals were included in this study. They completed a comprehensive assessment, including the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet(CERAD-K), and a past psychiatric/medical history interview. Depressive symptoms were assessed using the revised Korean version of the Geriatric Depression Scale(GDS-KR). All patients were divided into three groups, aMCI group, non-amnestic mild cognitive impairment(naMCI) group, and cognitively normal group. We defined factor based score as total score of items belonging to each factor of GDS-KR. We compared depressive symptoms among three groups based on factor based score.
Results：The GDS-KR was meaningfully factored into five clearly separated factors(sad mood and agitation, positive mood, lack of energy, cognitive inefficiency, social withdrawal). In the factor of ‘lack of energy’, there was a significant difference among the three groups(p=0.048). In post-hoc analysis, the ‘lack of energy’ factor based score of aMCI was higher than that of the cognitively normal group(p=0.044).
Conclusion：These findings suggest that the pathophysiology of depression in aMCI may differ from that of depression in cognitively normal group. It is important to focus on lack of energy in treating depressive symptoms in aMCI.
Methods：Three hundred and thirty two individuals were included in this study. They completed a comprehensive assessment, including the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet(CERAD-K), and a past psychiatric/medical history interview. Depressive symptoms were assessed using the revised Korean version of the Geriatric Depression Scale(GDS-KR). All patients were divided into three groups, aMCI group, non-amnestic mild cognitive impairment(naMCI) group, and cognitively normal group. We defined factor based score as total score of items belonging to each factor of GDS-KR. We compared depressive symptoms among three groups based on factor based score.
Results：The GDS-KR was meaningfully factored into five clearly separated factors(sad mood and agitation, positive mood, lack of energy, cognitive inefficiency, social withdrawal). In the factor of ‘lack of energy’, there was a significant difference among the three groups(p=0.048). In post-hoc analysis, the ‘lack of energy’ factor based score of aMCI was higher than that of the cognitively normal group(p=0.044).
Conclusion：These findings suggest that the pathophysiology of depression in aMCI may differ from that of depression in cognitively normal group. It is important to focus on lack of energy in treating depressive symptoms in aMCI.
목차
서론
연구 방법
결과
고찰
참고문헌
참고문헌 (38)
참고문헌 신청
[기타자료] - Statics / 2016 / 2015 Social indicators in Korea : 59 ~ 65
[보고서] - 보건복지부 / 2008 / 치매유병률조사 최종보고서
[학술지(정기간행물)] - Petersen RC / 2004 / Mild cognitive impairment as a diagnostic entity / J Intern Med 256 : 183 ~ 194
[학술지(정기간행물)] - Petersen RC / 2001 / Current concepts in mild cognitive impairment / Arch Neurol 58 : 1985 ~ 1992
[학술지(정기간행물)] - Flicker C / 1991 / Mild cognitive impairment in the elderly: predictors of dementia / Neurology 41 : 1006 ~ 1009
[보고서] - 보건복지부 / 2008 / 치매유병률조사 최종보고서
[학술지(정기간행물)] - Petersen RC / 2004 / Mild cognitive impairment as a diagnostic entity / J Intern Med 256 : 183 ~ 194
[학술지(정기간행물)] - Petersen RC / 2001 / Current concepts in mild cognitive impairment / Arch Neurol 58 : 1985 ~ 1992
[학술지(정기간행물)] - Flicker C / 1991 / Mild cognitive impairment in the elderly: predictors of dementia / Neurology 41 : 1006 ~ 1009
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UCI(KEPA) : I410-ECN-0101-2017-512-002188570