지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.5
- 수록면
- 1 - 9 (9page)
- DOI
- 10.3346/jkms.2023.38.e131
이용수
초록· 키워드
오류제보하기
Background: Early and appropriate diagnosis of amnestic mild cognitive impairment (aMCI) is clinically important because aMCI is considered the prodromal stage of dementia caused by Alzheimer’s disease (AD). aMCI is assessed using the comprehensive neuropsychological (NP) battery, but it is rater-dependent and does not provide quick results. Thus, we investigated the performance of the computerized cognitive screening test (Inbrain Cognitive Screening Test; Inbrain CST) in the diagnosis of aMCI and compared its performance to that of the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) test (CERAD-K), a comprehensive and pencil-and-paper NP test.
Methods: A total of 166 participants were included in this cross-sectional study. The participants were recruited as part of a prospective, community-based cohort study for MCI (PREcision medicine platform for mild cognitive impairment on multi-omics, imaging, evidence-based R&BD; PREMIER). All participants were assessed using the CERAD-K and the Inbrain CST. The Inbrain CST comprised seven subtests that assessed the following five cognitive domains: attention, language, visuospatial, memory, and executive functions. Seventy-six participants underwent brain magnetic resonance imaging and [18F]-flutemetamol positron emission tomography (PET). We evaluated the diagnostic performance of the Inbrain CST for the identification of aMCI by comparing the findings with those of CERAD-K. We also determined the characteristics of aMCI patients as defined by the CERAD-K and Inbrain CST.
Results: Of the 166 participants, 93 were diagnosed with aMCI, while 73 were cognitively unimpaired. The sensitivity of the Inbrain CST for aMCI diagnosis was 81.7%, and its specificity was 84.9%. Positive and negative predictive values were 87.4% and 78.5%, respectively. The diagnostic accuracy was 83.1%, and the error rate was 16.9%. Demographic and clinical characteristics between individuals with aMCI defined by the Inbrain CST and CERAD-K were not significantly different. The frequency of positive amyloid PET scan, the hippocampal/ parahippocampal volumes, and AD signature cortical thickness did not differ between the patients with aMCI defined by CERAD-K and those with aMCI defined by the Inbrain CST.
Conclusion: The Inbrain CST showed sufficient sensitivity, specificity, and positive and negative predictive values for diagnosing objective memory impairment in aMCI. In addition, aMCI patients identified by CERAD-K and the Inbrain CST showed comparable clinical and neuroimaging characteristics. Therefore, the Inbrain CST can be considered an alternative test to supplement the limitations of existing pencil-and-paper NP tests.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
지역사회 기억상실 경도인지장애 조기발견을 위한 2가지 다단계 프로그램 비교
노인정신의학
2020 .01
-
Distinct Neural Correlates of Executive Function by Amyloid Positivity and Associations with Clinical Progression in Mild Cognitive Impairment
Yonsei Medical Journal
2019 .01
-
Qualitative Comparison of Semantic Memory Impairment in Patients with Amnestic Mild Cognitive Impairment Based on β-Amyloid Status
Journal of Clinical Neurology
2019 .01
-
A Comparison of Memory Beliefs, Cognitive Activity, and Depression Among Healthy Older Adults, Amnestic Mild Cognitive Impairment, and Patient with Alzheimer's Disease
Annals of geriatric medicine and research
2019 .01
-
기억장애성 경도인지장애 환자의 양전자방출단층촬영검사에서 아밀로이드 침착이 해마 대사량에 미치는 영향 : 예비연구
생물치료정신의학
2019 .10
-
기억성 경도인지장애환자의 우울증상 특성
생물치료정신의학
2017 .02
-
기억 장애 환자에서 수면의 질과 인지기능과의 관련성
Journal of sleep medicine
2020 .01
-
Discriminative Power of Seoul Cognitive Status Test in Differentiating Subjective Cognitive Decline, Amnestic Mild Cognitive Impairment, and Dementia Based on CERAD-K Standards
Dementia and Neurocognitive Disorders(대한치매학회지)
2024 .07
-
The Effect of Clinical Characteristics and Subtypes on Amyloid Positivity in Patients with Amnestic Mild Cognitive Impairment
Dementia and Neurocognitive Disorders(대한치매학회지)
2019 .01
-
Diagnostic Validity of an Automated Probabilistic Tractography in Amnestic Mild Cognitive Impairment
Clinical Psychopharmacology and Neuroscience
2018 .01
-
Thalamic Shape and Cognitive Performance in Amnestic Mild Cognitive Impairment
PSYCHIATRY INVESTIGATION
2016 .01
-
Gender Differences in Items of the Instrumental Activities of Daily Living in Mild Cognitive Impairment and Alzheimer’s Disease Dementia
Dementia and Neurocognitive Disorders(대한치매학회지)
2024 .04
-
기억장애성 경도인지장애 환자에서 해마대사량의 감소: 양전자방출단층촬영연구
노인정신의학
2020 .01
-
A Comparison of Speech Features between Mild Cognitive Impairment and Healthy Aging Groups
Dementia and Neurocognitive Disorders(대한치매학회지)
2021 .10
-
Diagnosis and evaluation criteria for mild cognitive impairment in the field of animal assisted intervention
한국실험동물학회 학술발표대회 논문집
2021 .07
-
경도 인지장애 선별을 위한 전산화 인지기능 평가에 대한 체계적 고찰
대한작업치료학회지
2016 .01
-
경도인지장애 노인의 개인별 인지기능강화 프로그램적용의 효과
지역사회간호학회지
2015 .03
-
Comparison of Amyloid Positivity Rate and Accumulation Pattern between Amnestic and Non-Amnestic Type Mild Cognitive Impairment
PSYCHIATRY INVESTIGATION
2020 .01
-
Systematic Review of Diagnostic Accuracy of Fluorodeoxyglucose Positron Emission Tomography for Alzheimer’s Disease
보건의료기술평가
2017 .12
-
Usefulness of the Clock Drawing Test as a Cognitive Screening Instrument for Mild Cognitive Impairment and Mild Dementia: an Evaluation Using Three Scoring Systems
Dementia and Neurocognitive Disorders(대한치매학회지)
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0