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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.92 No.4
- 발행연도
- 2017.4
- 수록면
- 173 - 178 (6page)
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초록· 키워드
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Purpose: To evaluate the diagnostic accuracy of routine calcitonin measurement in patients with nodular thyroid disease.
Methods: Consecutive patients with nodular thyroid disease (n = 640) were studied. Serum calcitonin levels were measured under basal conditions, and when basal values were between 10–100 pg/mL, testing was repeated after pentagastrin (PG) stimulation. Patients with previously diagnosed or familial medullary thyroid cancer (MTC) were excluded. Patients were operated on when basal or stimulated calcitonin >100 pg/mL or when other surgical indications were present.
Results: Four cases of MTC were identified. MTC was diagnosed in 75% of patients with basal calcitonin >100 pg/mL. One out of 11 patients with basal calcitonin between 10–100 pg/mL was diagnosed with MTC. PG stimulation resulted in elevation in 4 cases, where 1 case was diagnosed with MTC. Positive predictive value for basal calcitonin levels in the preoperative diagnosis of MTC was 5% for values between 10–100 pg/mL and 100% for values >100 pg/mL. Possible reasons for false positivity were papillary thyroid cancer in 17%, renal insufficiency in 8.3%, Hashimoto thyroiditis in 17% and β-blocker use in 33%. Positive predictive value for the PG test (>100 pg/mL) was 25% in the entire series. The cost of adding calcitonin measurement (±PG stimulation) to the preoperative work-up, resulted in €912.68 per MTC patient to detect the disease.
Conclusion: Basal calcitonin measurement together with PG stimulation in cases of basal calcitonin >10 pg/mL detects MTC in 0.62% of patients with nodular thyroid disease.
Methods: Consecutive patients with nodular thyroid disease (n = 640) were studied. Serum calcitonin levels were measured under basal conditions, and when basal values were between 10–100 pg/mL, testing was repeated after pentagastrin (PG) stimulation. Patients with previously diagnosed or familial medullary thyroid cancer (MTC) were excluded. Patients were operated on when basal or stimulated calcitonin >100 pg/mL or when other surgical indications were present.
Results: Four cases of MTC were identified. MTC was diagnosed in 75% of patients with basal calcitonin >100 pg/mL. One out of 11 patients with basal calcitonin between 10–100 pg/mL was diagnosed with MTC. PG stimulation resulted in elevation in 4 cases, where 1 case was diagnosed with MTC. Positive predictive value for basal calcitonin levels in the preoperative diagnosis of MTC was 5% for values between 10–100 pg/mL and 100% for values >100 pg/mL. Possible reasons for false positivity were papillary thyroid cancer in 17%, renal insufficiency in 8.3%, Hashimoto thyroiditis in 17% and β-blocker use in 33%. Positive predictive value for the PG test (>100 pg/mL) was 25% in the entire series. The cost of adding calcitonin measurement (±PG stimulation) to the preoperative work-up, resulted in €912.68 per MTC patient to detect the disease.
Conclusion: Basal calcitonin measurement together with PG stimulation in cases of basal calcitonin >10 pg/mL detects MTC in 0.62% of patients with nodular thyroid disease.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (27)
참고문헌 신청
[학술지(정기간행물)] - Kebebew E / 2000 / Medullary thyroid carcinoma : clinical characteristics, treatment, prognostic factors, and a comparison of staging systems / Cancer 88 : 1139 ~ 1148
[학술지(정기간행물)] - Roman S / 2006 / Prognosis of medullary thyroid carcinoma : demographic, clinical, and pathologic predictors of survival in 1252 cases / Cancer 107 : 2134 ~ 2142
[학술지(정기간행물)] - Ozgen AG / 1999 / Evaluation of routine basal serum calcitonin measurement for early diagnosis of medullary thyroid carcinoma in seven hundred seventy-three patients with nodular goiter / Thyroid 9 : 579 ~ 582
[학술지(정기간행물)] - Rieu M / 1995 / Prevalence of sporadic medullary thyroid carcinoma : the importance of routine measurement of serum calcitonin in the diagnostic evaluation of thyroid nodules / Clin Endocrinol(Oxf) 42 : 453 ~ 460
[학술지(정기간행물)] - Vierhapper H / 1997 / Routine measurement of plasma calcitonin in nodular thyroid diseases / J Clin Endocrinol Metab 82 : 1589 ~ 1593
[학술지(정기간행물)] - Roman S / 2006 / Prognosis of medullary thyroid carcinoma : demographic, clinical, and pathologic predictors of survival in 1252 cases / Cancer 107 : 2134 ~ 2142
[학술지(정기간행물)] - Ozgen AG / 1999 / Evaluation of routine basal serum calcitonin measurement for early diagnosis of medullary thyroid carcinoma in seven hundred seventy-three patients with nodular goiter / Thyroid 9 : 579 ~ 582
[학술지(정기간행물)] - Rieu M / 1995 / Prevalence of sporadic medullary thyroid carcinoma : the importance of routine measurement of serum calcitonin in the diagnostic evaluation of thyroid nodules / Clin Endocrinol(Oxf) 42 : 453 ~ 460
[학술지(정기간행물)] - Vierhapper H / 1997 / Routine measurement of plasma calcitonin in nodular thyroid diseases / J Clin Endocrinol Metab 82 : 1589 ~ 1593
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UCI(KEPA) : I410-ECN-0101-2017-514-002372341