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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.22 No.2
- 발행연도
- 2017.6
- 수록면
- 81 - 89 (9page)
이용수
초록· 키워드
오류제보하기
Healthy aging has become a major goal of public health. Many studies have provided evidence and theories to explain molecular mechanisms of the aging process. Recent studies suggest that epigenetic mechanisms are responsible for life span and the progression of aging. Epigenetics is a fascinating field of molecular biology, which studies heritable modifications of DNA and histones that regulate gene expression without altering the DNA sequence. DNA methylation is a major epigenetic mark that shows progressive changes during aging. Recent studies have investigated aging-related DNA methylation as a biomarker that predicts cellular age. Interestingly, growing evidence proposes that nutrients play a crucial role in the regulation of epigenetic modifiers. Because various nutrients and their metabolites function as substrates or cofactors for epigenetic modifiers, nutrition can modulate or reverse epigenetic marks in the genome as well as expression patterns. Here, we will review the results on aging-associated epigenetic modifications and the possible mechanisms by which nutrition, including nutrient availability and bioactive compounds, regulate epigenetic changes and affect aging physiology.
목차
ABSTRACT
INTRODUCTION
MOLECULAR FACTORS IN AGING
EPIGENETIC AND AGING
EPIGENETIC LINK BETWEEN NUTRITION AND LONGEVITY
CONCLUSIONS
REFERENCES
참고문헌 (82)
참고문헌 신청
[학술지(정기간행물)] - Karasik D / 2005 / Disentangling the genetic determinants of human aging : biological age as an alternative to the use of survival measures / J Gerontol A Biol Sci Med Sci 60 : 574 ~ 587
[학술지(정기간행물)] - Deelen J / 2014 / Genomewide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age / Hum Mol Genet 23 : 4420 ~ 4432
[학술지(정기간행물)] - Willcox BJ / 2008 / FOXO3A genotype is strongly associated with human longevity / Proc Natl Acad Sci USA 105 : 13987 ~ 13992
[학술지(정기간행물)] - Nebel A / 2009 / A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians / Mech Ageing Dev 130 : 691 ~ 699
[학술지(정기간행물)] - Han J / 2013 / Discovery of novel nonsynonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next-generation sequencing / Mech Ageing Dev 134 : 478 ~ 485
[학술지(정기간행물)] - Deelen J / 2014 / Genomewide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age / Hum Mol Genet 23 : 4420 ~ 4432
[학술지(정기간행물)] - Willcox BJ / 2008 / FOXO3A genotype is strongly associated with human longevity / Proc Natl Acad Sci USA 105 : 13987 ~ 13992
[학술지(정기간행물)] - Nebel A / 2009 / A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians / Mech Ageing Dev 130 : 691 ~ 699
[학술지(정기간행물)] - Han J / 2013 / Discovery of novel nonsynonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next-generation sequencing / Mech Ageing Dev 134 : 478 ~ 485
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