지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.10
- 수록면
- 273 - 282 (10page)
이용수
초록· 키워드
오류제보하기
Chemoprevention entails the use of synthetic agents or naturally occurring dietary phytochemicals to prevent cancer development and progression. One promising chemopreventive agent, procyanidin, is a naturally occurring polyphenol that exhibits beneficial health effects including anti-inflammatory, antiproliferative, and antitumor activities. Currently, many preclinical reports suggest procyanidin as a promising lead compound for cancer prevention and treatment. As a potential anticancer agent, procyanidin has been shown to inhibit the proliferation of various cancer cells in "in vitro and in vivo". Procyanidin has numerous targets, many of which are components of intracellular signaling pathways, including proinflammatory mediators, regulators of cell survival and apoptosis, and angiogenic and metastatic mediators, and modulates a set of upstream kinases, transcription factors, and their regulators. Although remarkable progress characterizing the molecular mechanisms and targets underlying the anticancer properties of procyanidin has been made in the past decade, the chemopreventive targets or biomarkers of procyanidin action have not been completely elucidated. This review focuses on the apoptosis and tumor inhibitory effects of procyanidin with respect to its bioavailability.
목차
INTRODUCTION
CHEMOPREVENTIVE POTENTIAL OF PROCYANIDIN
CONCLUSIONS
REFERENCES
참고문헌 (95)
참고문헌 신청
Doll, R / 1981 / The causes of cancer, quantitative estimates of risks of cancer in the United States today / J. Natl. Cancer Inst 66:1191~1308
Riboli, E / 2003 / Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk / Am. J. Clin. Nutr 78:559S~569S
Willet, W.C / 1990 / Relation of meat, fat, and fiber intake to the risk of colon cancer in a prospective study among women / N. Engl. J. Med 323:1664~1672
Glade, M.J / 1997 / Food, nutrition, and the prevention of cancer, a global perspective. American institute for cancer research/World cancer research fund, American Institute for Cancer Research / Nutrition 15:523~526
Zhao, J / 1999 / Antitumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5-3'-gallate as the most effective antioxidant constituent / Carcinogenesis 20:1737~1745
Riboli, E / 2003 / Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk / Am. J. Clin. Nutr 78:559S~569S
Willet, W.C / 1990 / Relation of meat, fat, and fiber intake to the risk of colon cancer in a prospective study among women / N. Engl. J. Med 323:1664~1672
Glade, M.J / 1997 / Food, nutrition, and the prevention of cancer, a global perspective. American institute for cancer research/World cancer research fund, American Institute for Cancer Research / Nutrition 15:523~526
Zhao, J / 1999 / Antitumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5-3'-gallate as the most effective antioxidant constituent / Carcinogenesis 20:1737~1745
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UCI(KEPA) : I410-ECN-0101-2018-513-001357703