Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

Rohini Gomathinayagam; Ji Hee Ha; Muralidharan Jayaraman; 송용상; Ciro Isidoro; Danny N. Dhanasekaran

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자료유형: 학술저널

저자정보: Rohini Gomathinayagam (The University of Oklahoma Health Sciences Center) Ji Hee Ha (The University of Oklahoma Health Sciences Center) Muralidharan Jayaraman (The University of Oklahoma Health Sciences Center) 송용상 (서울대학교) Ciro Isidoro (Università del Piemonte Orientale) Danny N. Dhanasekaran (The University of Oklahoma Health Sciences Center)

저널정보: 대한암예방학회 대한암예방학회지 대한암예방학회지 제25권 제3호

발행연도: 2020.1

수록면: 136 - 151 (16page)

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Thymoquinone (TQ) is a bioactive component derived from the seeds of Nigella sativa that are commonly as black cumin. Evidences indicate that the medicinal properties of TQ have been recognized for more than 2000 years. TQ has been shown to possess potent chemopreventive properties that include anti-inflammatory and anti-neoplastic activities. Recent studies have unraveled the multiple mechanisms through which TQ exerts its chemopreventive and anticancer activity in different cancer cells in a contextual manner. The present review aims to provide a brief compendium on the molecular mechanisms through which TQ inhibits signaling pathways underlying cancer genesis, progression, and metastasis.

#Nigella sativa #Thymoquinone #Neoplasms #Chemoprevention #Antineoplastic agent

참고문헌 (141)

참고문헌 신청

Khalife KH / 2007 / Nonenzymatic reduction of thymoquinone in physiological conditions / Free Radic Res 41:153~161

Tekbas A / 2018 / Plants and surgery : the protective effects of thymoquinone on hepatic injury-a systematic review of in vivo studies / Int J Mol Sci 19:1085

Asaduzzaman Khan M / 2017 / Thymoquinone, as an anticancer molecule : from basic research to clinical investigation / Oncotarget 8:51907~51919

Ahmad A / 2019 / Thymoquinone(2-Isoprpyl-5-methyl-1, 4-benzoquinone)as a chemopreventive/anticancer agent : chemistry and biological effects / Saudi Pharm J 27:1113~1126

Fatfat M / 2019 / Thymoquinone enhances the anticancer activity of doxorubicin against adult T-cell leukemia in vitro and in vivo through ROSdependent mechanisms / Life Sci 232:116628

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