Chemopreventive and Chemotherapeutic Effect of Propolis and Its Constituents: A Mini-review

Hui-Fang Chiu; Yi-Chun Han; You-Cheng Shen; Oksana Golovinskaia; Kamesh Venkatakrishnan; Chin-Kun Wang

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자료유형: 학술저널

저자정보: Hui-Fang Chiu (Taichung Hospital Ministry of Health and Well-being) Yi-Chun Han (Chung Shan Medical University) You-Cheng Shen (Chung Shan Medical University) Oksana Golovinskaia (ITMO University) Kamesh Venkatakrishnan (Chung Shan Medical University) Chin-Kun Wang (Chung Shan Medical University)

저널정보: 대한암예방학회 대한암예방학회지 대한암예방학회지 제25권 제2호

발행연도: 2020.1

수록면: 70 - 78 (9page)

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Propolis is a bee wax rich in various phytocomponents and traditionally used to treat various ailments. Propolis is reported to possess an array of biological properties including anti-inflammatory, antioxidant, anti-cancer, and anti-diabetic as well as cardioprotective, hepatoprotective, renoprotective, and derma protective activities. A plethora of studies confirmed that propolis is effective against various types of cancer including head and neck, lung, liver, brain (glioma), pancreas, kidney, prostate, skin (melanoma), breast, oral, esophagus, gastric, colorectal, and bladder cancers. However, many researchers have demonstrated that propolis displays potent chemoprotective/chemopreventive or anti-cancer activity against only a few types of cancers like oral, gastrointestinal, dermal (melanoma), breast, and prostate cancers. Therefore, this mini-review only summarizes the chemopreventive/chemotherapeutic activities of propolis and its updated underlying mechanisms. Taken together, propolis displays potent chemoprotective or anti-cancer effect due to the presence of various phytocomponents which contribute to pro-apoptotic, cytotoxic, anti-proliferative (cell cycle arrest), anti-metastatic, anti-invasive, anti-angiogenic and anti-genotoxic or anti-mutagenic properties along with antioxidant, immunomodulatory, and anti-inflammatory functions. Hence, propolis could be used as an adjuvant for treating various cancers along with standard chemotherapeutic drugs. However, many large-scale clinical studies are needed to justify such applications.

#Propolis #Anti-cancer #Adjuvant therapy #Apoptosis #Chemotherapeutic drugs

참고문헌 (89)

참고문헌 신청

Yumnam R / 2017 / Effect of propolis in oral health / J Ayurveda Integr Med Sci 2:186~192

Pasupuleti VR / 2017 / Honey, propolis, and royal jelly : a comprehensive review of their biological actions and health benefits / Oxid Med Cell Longev 2017:1259510

Sforcin JM / 2017 / Medical benefits of honeybee products / Evid Based Complement Alternat Med 2017:2702106

Sforcin JM / 2007 / Propolis and the immune system : a review / J Ethnopharmacol 113:1~14

Pobiega K / 2017 / Antimicrobial and antiviral properties of different types of propolis / Zesz Probl Postęp Nauk Rol 589:69~79

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