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논문 기본 정보

자료유형
학술저널
저자정보
Keeton K. Krause (University of Hawaii at Manoa) Francine Azouz (University of Hawaii at Manoa) Ok Sarah Shin (Korea University College of Medicine) Mukesh Kumar (University of Hawaii at Manoa)
저널정보
대한면역학회 Immune Network Immune Network Vol.17 No.5
발행연도
2017.10
수록면
287 - 297 (11page)

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초록· 키워드

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Zika virus (ZIKV) is a member of Flaviviridae family that has emerged as a pathogen of significant public health importance. The rapid expansion of ZIKV in the South and Central America has recently gained medical attention emphasizing the capacity of ZIKV to spread to non-endemic regions. ZIKV infection during pregnancy has been demonstrated to cause microcephaly and other fetal developmental abnormalities. An increased incidence of Guillain-Barre syndrome, an immune mediated neuropathy of the peripheral nervous system, has also been reported in ZIKV-infected patients in French Polynesia and Brazil. No effective therapies currently exist for treating patients infected with ZIKV. Despite the relatively short time interval, an intensive effort by the global scientific community has resulted in development of animal models to study multiple aspects of ZIKV biology. Several animal models have been established to investigate pathogenesis of ZIKV in adults, pregnant mothers, and developing fetuses. Here we review the remarkable progress of newly developed small and large animal models for understanding ZIKV pathogenesis.

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ABSTRACT
INTRODUCTION
ANIMAL MODELS OF ZIKV INFECTION
SMALL ANIMAL MODELS OF ZIKV INFECTION
LARGE ANIMAL MODELS OF ZIKV INFECTION
CONCLUSION
REFERENCES

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UCI(KEPA) : I410-ECN-0101-2018-517-001400652