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논문 기본 정보

자료유형
학술저널
저자정보
여효성 (계명대학교) 홍영표 (한국체육대학교) 이삼준 (동명대학교)
저널정보
한국체육과학회 한국체육과학회지 한국체육과학회지 제26권 제5호 (자연과학 편)
발행연도
2017.10
수록면
1,039 - 1,048 (10page)
DOI
10.35159/kjss.2017.10.26.5.1039

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초록· 키워드

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Schizophrenia is a neuropsychiatric disease accompanying with psychological, emotional and behavioral disorders. Lifespan of patients with schizophrenia is 11 to 20 years shorter than general people which might be associated with cardiovascular disease. Although apoptosis is highly related to cardiovascular disease, to date there is no study observing apoptotis in heart with schizophrenia. Therefore, we tried to investigate the expression of apoptotic proteins in rats with schizophrenia and the effect of regular aerobic exercise. Twenty-one SD rats were assigned to CON (control, n=7), SCH (schizophrenia, n=7), SCH+EXE (schizophrenia+exercise, n=7) groups. SCH and SCH+EXE groups were treated with MK-801 using i.p. injection for schizophrenia. SCH+EXE group ran on the rodent treadmill at 2 2m/min for f our w eeks ( 5days/week, 3 0min/day). A poptotic p roteins including b ax, bcl-2, cytochrome-c, caspase-3 in left ventricle were analyzed by western blotting. From the results, the expression of bax (p=.001), cytochrome-c (p=.035) and caspase-3 (p=.001) in SCH group were significantly higher than in CON group. On contrary, SCH+EXE group showed the significantly lower expression of bax (p=.009) and caspase-3 (p=.027) than CON group. There was no difference of bcl-2 protein between groups (p>.05), however bax/bcl-2 ratio was higher in SCH (p=.026) than in CON group, as well as it was lower in SCH+EXE (p=.004) than SCH group. These results suggest that increased apoptotic level in heart by inducing schizophrenia could be attenuated by regular aerobic exercise.

목차

Abstract
Ⅰ. 서론
Ⅱ. 연구방법
Ⅲ. 결과
Ⅳ. 논의
Ⅴ. 결론
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