지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.12
- 수록면
- 452 - 460 (9page)
이용수
초록· 키워드
오류제보하기
BACKGROUD/OBJECTIVES: Turanose, α-D-glucosyl-(1→3)-α-D-fructose, is a sucrose isomer which naturally exists in honey. To evaluate toxicity of turanose, acute and subchronic oral toxicity studies were conducted with ICR mice.
MATERIALS AND METHODS: For the acute oral toxicity study, turanose was administered as a single oral dose [10 g/㎏ body weight (b.w.)]. In the subchronic toxicity study, ICR mice were administered 0, 1.75, 3.5, and 7 g/㎏ b.w. doses of turanose daily for 13 weeks.
RESULTS: No signs of acute toxicity, including abnormal behavior, adverse effect, or mortality, were observed over the 14-day study period. In addition, no changes in body weight or food consumption were observed and the median lethal dose (LD50) for oral intake of turanose was determined to be greater than 10 g/㎏ b.w. General clinical behavior, changes in body weight and food consumption, absolute and relative organ weights, and mortality were not affected in any of the treatment group for 13 weeks. These doses also did not affect the macroscopic pathology, histology, hematology, and blood biochemical analysis of the mice examined.
CONCLUSION: No toxicity was observed in the acute and 13-week subchronic oral toxicology studies that were conducted with ICR mice. Furthermore, the no-observed-adverse-effect level is greater than 7 g/㎏/day for both male and female ICR mice.
MATERIALS AND METHODS: For the acute oral toxicity study, turanose was administered as a single oral dose [10 g/㎏ body weight (b.w.)]. In the subchronic toxicity study, ICR mice were administered 0, 1.75, 3.5, and 7 g/㎏ b.w. doses of turanose daily for 13 weeks.
RESULTS: No signs of acute toxicity, including abnormal behavior, adverse effect, or mortality, were observed over the 14-day study period. In addition, no changes in body weight or food consumption were observed and the median lethal dose (LD50) for oral intake of turanose was determined to be greater than 10 g/㎏ b.w. General clinical behavior, changes in body weight and food consumption, absolute and relative organ weights, and mortality were not affected in any of the treatment group for 13 weeks. These doses also did not affect the macroscopic pathology, histology, hematology, and blood biochemical analysis of the mice examined.
CONCLUSION: No toxicity was observed in the acute and 13-week subchronic oral toxicology studies that were conducted with ICR mice. Furthermore, the no-observed-adverse-effect level is greater than 7 g/㎏/day for both male and female ICR mice.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (16)
참고문헌 신청
Augustin LS, Franceschi S, Jenkins DJ, Kendall CW, La Vecchia C. Glycemic index in chronic disease: a review. Eur J Clin Nutr 2002;56:1049-71.
Livesey G, Taylor R, Hulshof T, Howlett J. Glycemic response and health--a systematic review and meta-analysis: relations between dietary glycemic properties and health outcomes. Am J Clin Nutr 2008;87:258S-268S.
Holub I, Gostner A, Theis S, Nosek L, Kudlich T, Melcher R, Scheppach W. Novel findings on the metabolic effects of the low glycaemic carbohydrate isomaltulose (Palatinose). Br J Nutr 2010; 103:1730-7.
Malik VS, Schulze MB, Hu FB. Intake of sugar-sweetened beverages and weight gain: a systematic review. Am J Clin Nutr 2006;84: 274-88.
White JW, Hoban N. Composition of honey. IV. Identification of the disaccharides. Arch Biochem Biophys 1959;80:386-92.
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Acute and 13-week subchronic toxicological evaluations of turanose in mice
Nutrition Research and Practice
2017 .12
-
급성알코올 독성을 유발한 ICR Mouse에서 Allium hookeri 뿌리 에탄올 추출물의 간 보호 효과
한국생활과학회 학술대회논문집
2015 .11
-
Phenotyping analysis of p53 knockout mice produced by gene editing and comparison with conventional p53 knockout mice
Genes & Genomics
2019 .01
-
Evaluation of Abeliophyllum distichum Nakai Extract on Wound Healing Ability in ICR Mouse and Antibacterial Activity against Human Cutaneous Flora
한국미생물학회 학술대회논문집
2021 .08
-
Protective effects of P2X7 receptor deletion on aging-related memory alterations
Genes & Genomics
2016 .01
-
Theory and application of 2 omega 7T FT-ICR MS for ultra-high resolution analysis of complex organic mixture
한국분석과학회 학술대회
2016 .11
-
ICR 마우스를 이용한 산수유 건피 추출물의 단회 경구투여 독성시험
생명과학회지
2019 .01
-
Optimization of Mouse Model Experiments for Development of Functional Verification Platform Technology
한국미생물학회 학술대회논문집
2022 .10
-
Effect of parasitic infection on muscular function of dystrophin gene (Dmd) deficient mouse
Genes & Genomics
2023 .02
-
Study on Organic Molecular Distribution and Characteristics via Analysis of Natural Organic Matter (NOM) in Korean Spring water Using 15T FT-ICR MS
한국분석과학회 학술대회
2019 .11
-
Study on Organic Molecular Distribution and Characteristics via Analysis of Natural Organic Matter (NOM) in Korean Spring water Using 15T FT-ICR MS
한국분석과학회 학술대회
2019 .11
-
Effects of the fermented Zizyphus jujuba in the amyloid β25-35-induced Alzheimer"s disease mouse model
Nutrition Research and Practice
2021 .04
-
Effects of the fermented Zizyphus jujuba in the amyloid β25-35-induced Alzheimer"s disease mouse model
Nutrition Research and Practice
2021 .04
-
Toxicity assessment based on non-targeted metabolomics study of natural deep eutectic solvents in in vivo mice
한국분석과학회 학술대회
2020 .06
-
Toxicity assessment based on non-targeted metabolomics study of natural deep eutectic solvents in in vivo mice
한국분석과학회 학술대회
2020 .06
-
Immunomodulatory Potential of Weissella cibaria in Aged C57BL/6J Mice
Journal of Microbiology and Biotechnology
2017 .01
-
Similarities and differences between alpha-tocopherol and gamma-tocopherol in amelioration of inflammation, oxidative stress and pre-fibrosis in hyperglycemia induced acute kidney inflammation
Nutrition Research and Practice
2016 .02
-
Similarities and differences between alpha-tocopherol and gamma-tocopherol in amelioration of inflammation, oxidative stress and pre-fibrosis in hyperglycemia induced acute kidney inflammation
Nutrition Research and Practice
2016 .02
-
ICR 마우스를 이용한 오미자, 상엽 에탄올 단독추출물 및 복합추출물의 단회경구투여 독성시험
생명과학회지
2016 .10
-
Human Fucosyltransferase 2 Expression in Mouse
한국미생물학회 학술대회논문집
2016 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2018-594-001546021