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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 459 - 465 (7page)
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Neuroinflammation is one of the factors implicated in cognitive aging. Recent studies have shown that the P2X7 receptor (P2X7R) is a major inflammatory regulator in microglia. The present study examined the effects of deletion of P2X7R on cognitive aging. Cognitive status was examined in 5-month-old (young) and 11- to 14-month-old (middle-aged) mice with P2X7R deletion (P2X7R knockout (KO)), and in age-matched control wild type mice, using the Morris water maze task. No differences were observed between the performances of young control mice and young P2X7R KO mice in the Morris water maze task. However, middle-aged P2X7R KO mice demonstrated better performance than middle-aged control mice. No differences were observed in hippocampal interleukin-1b levels and the number of microglial cells in the cornus ammonis (CA1) region of the hippocampus during microglial activation in young and middle-aged P2X7R KO mice, and control mice. Hippocampal levels of the inhibitory form of glycogen synthase kinase-3b were lower in young control mice than in mice in the other groups. These results suggest that the inhibition of P2X7R might have beneficial effects on aging-related cognitive impairments.
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참고문헌 (20)
참고문헌 신청
Arbeloa J / 2012 / P2X7 receptor blockade prevents ATP excitotoxicity in neurons and reduces brain damage after ischemia / Neurobiol Dis 45:954~961
Brough D / 2002 / Purinergic (P2X7) receptor activation of microglia induces cell death via an interleukin-1-independent mechanism / Mol Cell Neurosci 19:272~280
Chu K / 2012 / Inhibition of P2X7 receptor ameliorates transient global cerebral ischemia/reperfusion injury via modulating inflammatory responses in the rat hippocampus / J Neuroinflammation 9:69
Diaz-Hernandez JI / 2012 / In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer’s disease through GSK3beta and secretases / Neurobiol Aging 33:1816~1828
Gallagher M / 1993 / Severity of spatial learning impairment in aging: development of a learning index for performance in the Morris water maze / Behav Neurosci 107:618~626
Brough D / 2002 / Purinergic (P2X7) receptor activation of microglia induces cell death via an interleukin-1-independent mechanism / Mol Cell Neurosci 19:272~280
Chu K / 2012 / Inhibition of P2X7 receptor ameliorates transient global cerebral ischemia/reperfusion injury via modulating inflammatory responses in the rat hippocampus / J Neuroinflammation 9:69
Diaz-Hernandez JI / 2012 / In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer’s disease through GSK3beta and secretases / Neurobiol Aging 33:1816~1828
Gallagher M / 1993 / Severity of spatial learning impairment in aging: development of a learning index for performance in the Morris water maze / Behav Neurosci 107:618~626
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