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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제8호
- 발행연도
- 2017.1
- 수록면
- 1,529 - 1,538 (10page)
이용수
이 논문의 연구 히스토리 (2)
2017
Cooperative Interactions between TLR2 and TLR4 in Murine Klebsiella pneumoniae Infection : Toll-like receptor(TLR) 2와 4가 Klebsiella pneumoniae 감염에 미치는 상호 작용에 관한 연구
전희연
수의학과
2017.01
학위논문
Cooperative Interactions between Toll-Like Receptor 2 and Toll-Like Receptor 4 in Murine Klebsiella pneumoniae Infections
전희연
,
박종형
,
박진일
외 5명
Journal of Microbiology and Biotechnology
2017.01
학술저널
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Klebsiella pneumoniae is an opportunistic and clinically significant emerging pathogen. We investigated the relative roles of Toll-like receptor (TLR) 2 and TLR4 in initiating host defenses against K. pneumoniae. TLR2 knockout (KO), TLR4 KO, TLR2/4 double KO (DKO), and wildtype (WT) mice were inoculated with K. pneumoniae. Mice in each group were sacrificed after either 12 or 24h, and the lungs, liver, and blood were harvested to enumerate bacterial colonyforming units (CFU). Cytokine and chemokine levels were analyzed using enzyme-linked immunosorbent assay and real-time PCR, and pneumonia severity was determined by histopathological analysis. Survival was significantly shortened in TLR4 KO and TLR2/4 DKO mice compared with that of WT mice after infection with 5 × 103 CFU. TLR2 KO mice were more susceptible to infection than WT mice after exposure to a higher infectious dose.
Bacterial burdens in the lungs and liver were significantly higher in TLR2/4 DKO mice than in WT mice. Serum TNF-α, MCP-1, MIP-2, and nitric oxide levels were significantly decreased in TLR2/4 DKO mice relative to those in WT mice, and TLR2/4 DKO mice showed significantly decreased levels of TNF-α, IL-6, MCP-1, and inducible nitric oxide synthase mRNA in the lung compared with those in WT mice. Collectively, these data indicate that TLR2/4 DKO mice were more susceptible to K. pneumoniae infection than single TLR2 KO and TLR4 KO mice.
These results suggest that TLR2 and TLR4 play cooperative roles in lung innate immune responses and bacterial dissemination, resulting in systemic inflammation during K. pneumoniae infection.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Bhan U / 2010 / Cooperative interactions between TLR4and TLR9 regulate interleukin 23 and 17 production in a murine model of gram-negative bacterial pneumonia / PLoS One 5 :
Bogdan C. / 2001 / Nitric oxide and the immune response / Nat. Immunol 2 : 907 ~ 916
Branger J / 2004 / Role of Toll-like receptor 4 in grampositive and gram-negative pneumonia in mice / Infect. Immun 72 : 788 ~ 794
Gregory SH / 1993 / Reactive nitrogen intermediates suppress the primary immunologic response to Listeria / J. Immunol 150 : 2901 ~ 2909
Jeannin P / 2002 / Outer membrane protein A (OmpA): a new pathogen-associated molecular pattern that interacts with antigen presenting cells - impact on vaccine strategies /
Bogdan C. / 2001 / Nitric oxide and the immune response / Nat. Immunol 2 : 907 ~ 916
Branger J / 2004 / Role of Toll-like receptor 4 in grampositive and gram-negative pneumonia in mice / Infect. Immun 72 : 788 ~ 794
Gregory SH / 1993 / Reactive nitrogen intermediates suppress the primary immunologic response to Listeria / J. Immunol 150 : 2901 ~ 2909
Jeannin P / 2002 / Outer membrane protein A (OmpA): a new pathogen-associated molecular pattern that interacts with antigen presenting cells - impact on vaccine strategies /
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