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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 58 - 64 (7page)
- DOI
- http://www.molcells.org/journal/view.html?doi=10.14348/molcells.2015.2231
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초록· 키워드
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Activating transcription factor-3 (ATF3) acts as a negative regulator of cytokine production during Gram-negative bacterial infection. A recent study reported that ATF3 provides protection from Streptococcus pneumoniae infection by activating cytokines. However, the mechanism by which S.
pneumoniae induces ATF3 after infection is still unknown. In this study, we show that ATF3 was upregulated via Toll-like receptor (TLR) pathways in response to S. pneumoniae infection in vitro. Induction was mediated by TLR4 and TLR2, which are in the TLR family. The expression of ATF3 was induced by pneumolysin (PLY), a potent pneumococcal virulence factor, via the TLR4 pathway. Furthermore, ATF3 induction is mediated by p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK). Thus, this study reveals a potential role of PLY in modulating ATF3 expression, which is required for the regulation of immune responses against pneumococcal infection in macrophages.
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참고문헌 (35)
참고문헌 신청
Aung, H. H. / 2013 / Induction of ATF3 gene network by triglyceride-rich lipoprotein lipolysis products increases vascular apoptosis and inflammation / Arterioscler. Thromb. Vasc. Biol 33:2088~2096
Basset, A. / 2012 / Toll-like receptor(TLR)2 mediates inflammatory responses to oligomerized RrgA pneumococcal pilus type 1 protein / J. Biol. Chem 288:2665~2675
Benton, K. A. / 1995 / A pneumolysinnegative mutant of Streptococcus pneumoniae causes chronic bacteremia rather than acute sepsis in mice / Infect. Immun 63:448~455
Boespflug, N. D. / 2014 / ATF3 is a novel regulator of mouse neutrophil migration / Blood 123:2084~2093
Calton, C. M. / 2013 / Upregulation of ATF3inhibits expression of the pro-inflammatory cytokine IL-6 during Neisseria gonorrhoeae infection / Cell. Microbiol 15:1837~1850
Basset, A. / 2012 / Toll-like receptor(TLR)2 mediates inflammatory responses to oligomerized RrgA pneumococcal pilus type 1 protein / J. Biol. Chem 288:2665~2675
Benton, K. A. / 1995 / A pneumolysinnegative mutant of Streptococcus pneumoniae causes chronic bacteremia rather than acute sepsis in mice / Infect. Immun 63:448~455
Boespflug, N. D. / 2014 / ATF3 is a novel regulator of mouse neutrophil migration / Blood 123:2084~2093
Calton, C. M. / 2013 / Upregulation of ATF3inhibits expression of the pro-inflammatory cytokine IL-6 during Neisseria gonorrhoeae infection / Cell. Microbiol 15:1837~1850
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