지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.3
- 수록면
- 390 - 400 (11page)
- DOI
- 10.14348/molcells.2018.2078
이용수
초록· 키워드
오류제보하기
Studies have revealed that miR-103a-3p contributes to tumor growth in several human cancers, and high miR-103a-3p expression is associated with poor prognosis in advanced gastric cancer (GC) patients. Moreover, bioinformatics analysis has shown that miR-103a-3p is upregulated in The Cancer Genome Atlas (TCGA) stomach cancer cohort. These results suggest that miR-103a-3p may function as an oncogene in GC. The present study aimed to investigate the role of miR-103a-3p in human GC. miR-103a-3p expression levels were increased in 33 clinical GC specimens compared with adjacent nontumor stomach tissues. Gain- and loss-of-function studies were performed to identify the correlation between miR-103a-3p and tumorigenesis in human GC. Inhibiting miR-103a-3p suppressed GC cell proliferation and blocked the S-G2/M transition in MKN-45/SGC-7901 cells, whereas miR-103a-3p overexpression improved GC cell proliferation and promoted the S-G2/M transition in vitro. Bioin-formatics and dual-luciferase reporter assays confirmed that ATF7 is a direct target of miR-103a-3p. Analysis of the TCGA stomach cancer cohort further revealed that miR-103a-3p expression was inversely correlated with ATF7 expression. Notably, silencing ATF7 showed similar cellular and molecular effects as miR-103a-3p overexpression, namely, increased GC cell proliferation, improved CDK2 expression and decreased P27 expression. ATF7 overexpression eliminated the effects of miR-103a-3p expression. These findings indicate that miR-103a-3p promotes the proliferation of GC cell by targeting and suppressing ATF7 in vitro.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Arabpour, M. / 2016 / Circulating microRNAs as potential diagnostic biomarkers and therapeutic targets in gastric cancer: current status and future perspectives / Curr. Med. Chem. 23:4135~4150
Bang, Y.-J. / 2010 / Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial / The Lancet 376:687~697
Bray, F. / 2013 / Global estimates of cancer prevalence for 27 sites in the adult population in 2008 / Int. J. Cancer 132:1133~1145
Chen, H.Y. / 2012 / miR- 103/107 promote metastasis of colorectal cancer by targeting the metastasis suppressors DAPK and KLF4 / Cancer Res. 72:3631~3641
조화자 / 2009 / miR-372 Regulates Cell Cycle and Apoptosis of AGS Human Gastric Cancer Cell Line through Direct Regulation of LATS2 / Molecules and Cells 28(6):521~527
Bang, Y.-J. / 2010 / Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial / The Lancet 376:687~697
Bray, F. / 2013 / Global estimates of cancer prevalence for 27 sites in the adult population in 2008 / Int. J. Cancer 132:1133~1145
Chen, H.Y. / 2012 / miR- 103/107 promote metastasis of colorectal cancer by targeting the metastasis suppressors DAPK and KLF4 / Cancer Res. 72:3631~3641
조화자 / 2009 / miR-372 Regulates Cell Cycle and Apoptosis of AGS Human Gastric Cancer Cell Line through Direct Regulation of LATS2 / Molecules and Cells 28(6):521~527
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
MiR-1299 functions as a tumor suppressor to inhibit the proliferation and metastasis of gastric cancer by targeting ARF6
Genes & Genomics
2022 .02
-
miR-30a Regulates the Expression of CAGE and p53 and Regulates the Response to Anti-Cancer Drugs
Molecules and Cells
2016 .04
-
Circulating microRNA expression profiling in young obese Korean women
Nutrition Research and Practice
2020 .08
-
Cell-Free miR-27a, a Potential Diagnostic and Prognostic Biomarker for Gastric Cancer
Genomics & informatics
2015 .01
-
Comparison of the miR-23b and miR-203 Expressions in Endometrial Cancer
대한임상검사과학회지
2017 .01
-
LncRNA H19 Drives Proliferation of Cardiac Fibroblasts and Collagen Production via Suppression of the miR-29a-3p/miR-29b-3p-VEGFA/TGF-β Axis
Molecules and Cells
2022 .03
-
Circulating microRNA expression profiling in young obese Korean women
Nutrition Research and Practice
2020 .08
-
Overexpression of Long Non-Coding RNA MIR22HG Represses Proliferation and Enhances Apoptosis via miR-629-5p/TET3 Axis in Osteosarcoma Cells
Journal of Microbiology and Biotechnology
2021 .10
-
The seed sequence is necessary but insufficient for downregulation of target genes by miR-608
Genes & Genomics
2016 .01
-
Alteration of the Metabolome Profile in Endothelial Cells by Overexpression of miR-143/145
Journal of Microbiology and Biotechnology
2016 .01
-
Suppression of HELLS by miR-451a represses mTOR pathway to hinder aggressiveness of SCLC
Genes & Genomics
2021 .01
-
Hsa_Circ_0001947/MiR-661/DOK7 Axis Restrains Non-Small Cell Lung Cancer Development
Journal of Microbiology and Biotechnology
2021 .11
-
Tumor-suppressive miRNA-135a inhibits breast cancer cell proliferation by targeting ELK1 and ELK3 oncogenes
Genes & Genomics
2018 .01
-
MicroRNA?9 inhibits proliferation and progression in retinoblastoma cells by targeting PTEN
Genes & Genomics
2021 .09
-
Knockdown of Circ_0000144 Suppresses Cell Proliferation, Migration and Invasion in Gastric Cancer Via Sponging MiR-217
Journal of Microbiology and Biotechnology
2021 .01
-
Overexpression of microRNA-612 Restrains the Growth, Invasion, and Tumorigenesis of Melanoma Cells by Targeting Espin
Molecules and Cells
2018 .02
-
MicroRNA-576-3p Inhibits Proliferation in Bladder Cancer Cells by Targeting Cyclin D1
Molecules and Cells
2015 .02
-
폐암에서 microRNA 155의 발현 양상과 임상병리학적 의의
생명과학회지
2016 .09
-
miR-582-5p inhibits migration and chemo-resistant capabilities of colorectal cancer cells by targeting TNKS2
Genes & Genomics
2022 .06
-
MicroRNA‑377‑3p inhibits growth and invasion through sponging JAG1 in ovarian cancer
Genes & Genomics
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0