지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.2
- 수록면
- 130 - 137 (8page)
- DOI
- 10.14348/molcells.2015.2146
이용수
초록· 키워드
오류제보하기
MicroRNAs (miRNAs) are small, endogenous RNAs that play important gene-regulatory roles by binding to the imperfectly complementary sequences at the 3 -UTR of mRNAs and directing their gene expression. Here, we first discovered that miR-576-3p was down-regulated in human bladder cancer cell lines compared with the non-malignant cell line. To better characterize the role of miR-576-3p in bladder cancer cells, we over-expressed or down-regulated miR-576-3p in bladder cancer cells by transfecting with chemically synthesized mimic or inhibitor. The overexpression of miR-576-3p remarkably inhibited cell proliferation via G1-phase arrest, and decreased both mRNA and protein levels of cyclin D1 which played a key role in G1/S phase transition. The knock-down of miR-576-3p significantly promoted the proliferation of bladder cancer cells by accelerating the progression of cell cycle and increased the expression of cyclin D1. Moreover, the dual-luciferase reporter assays indicated that miR-576-3p could directly target cyclin D1 through binding its 3 -UTR. All the results demonstrated that miR-576-3p might be a novel suppressor of bladder cancer cell proliferation through targeting cyclin D1.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Allegra, A. / 2012 / Circulating microRNAs : new biomarkers in diagnosis, prognosis and treatment of cancer(review) / Int. J. Oncol 41:1897~1912
Bartel, D. P. / 2009 / MicroRNAs : target recognition and regulatory functions / Cell 136:215~233
Catto, J. W. / 2011 / MicroRNA in prostate, bladder, and kidney cancer : a systematic review / Eur. Urol 59:671~681
Chen, J. / 2010 / MicroRNA-193b represses cell proliferation and regulates cyclin D1 in melanoma / Am. J. Pathol 176:2520~2529
Cho, W. C. / 2010 / MicroRNAs: potential biomarkers for cancer diagnosis, prognosis and targets for therapy / Int. J. Biochem. Cell Biol 42:1273~1281
Bartel, D. P. / 2009 / MicroRNAs : target recognition and regulatory functions / Cell 136:215~233
Catto, J. W. / 2011 / MicroRNA in prostate, bladder, and kidney cancer : a systematic review / Eur. Urol 59:671~681
Chen, J. / 2010 / MicroRNA-193b represses cell proliferation and regulates cyclin D1 in melanoma / Am. J. Pathol 176:2520~2529
Cho, W. C. / 2010 / MicroRNAs: potential biomarkers for cancer diagnosis, prognosis and targets for therapy / Int. J. Biochem. Cell Biol 42:1273~1281
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