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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.4
- 수록면
- 299 - 309 (11page)
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We have previously reported the role of miR-217 in anti-cancer drug-resistance. miRNA array and miRNA hybridi-zation analysis predicted miR-30a-3p as a target of miR-217. miR-30a-3p and miR-217 formed a negative feedback loop and regulated the expression of each other. Ago1 immunoprecipitation and co-localization analysis revealed a possible interaction between miR-30a-3p and miR-217. miR-30a-3p conferred resistance to anti-cancer drugs and enhanced the invasion, migration, angiogenic, tumorigenic, and metastatic potential of cancer cells in CAGE-dependent manner. CAGE increased the expression of miR-30a-3p by binding to the promoter sequences of miR-30a-3p, suggesting a positive feedback loop between CAGE and miR-30a-3p. miR-30a-3p decreased the expression of p53, which showed the binding to the promoter sequences of miR-30a-3p and CAGE in anti-cancer drug-sensitive cancer cells. Luciferase activity assays showed that p53 serves as a target of miR-30a. Thus, the miR-30a-3p-CAGE-p53 feed-back loop serves as a target for overcoming resistance to anti-cancer drugs.
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참고문헌 (28)
참고문헌 신청
Bojmar, L. / 2013 / The role of microRNA-200 in progression of human colorectal and breast cancer / PLoS One 8:84815
Chaudhary, P. / 2014 / Inhibition of triple-negative and Herceptin-resistant breast cancer cell proliferation and migration by Annexin A2 antibodies / Br. J. Cancer 111:2328~2341
Chen, Z. / 2013 / miR-27a modulates the MDR1/P-glycoprotein expression by inhibiting FZD7/β-catenin pathway in hepatocellular carcinoma cells / Cell. Signal 25:2693~2701
Chen, W. / 2014 / MiR-136 targets E2F1 to reverse cisplatin chemosensitivity in glioma cells / J. Neurooncol 120:43~53
Chen, W. X. / 2014 / Exosomes from drug-resistant breast cancer cells transmit chemoresistance by a horizontal transfer of microRNAs / PLoS One 9:95240
Chaudhary, P. / 2014 / Inhibition of triple-negative and Herceptin-resistant breast cancer cell proliferation and migration by Annexin A2 antibodies / Br. J. Cancer 111:2328~2341
Chen, Z. / 2013 / miR-27a modulates the MDR1/P-glycoprotein expression by inhibiting FZD7/β-catenin pathway in hepatocellular carcinoma cells / Cell. Signal 25:2693~2701
Chen, W. / 2014 / MiR-136 targets E2F1 to reverse cisplatin chemosensitivity in glioma cells / J. Neurooncol 120:43~53
Chen, W. X. / 2014 / Exosomes from drug-resistant breast cancer cells transmit chemoresistance by a horizontal transfer of microRNAs / PLoS One 9:95240
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