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논문 기본 정보

자료유형
학술저널
저자정보
Hyunsu Lee (Keimyung University) Mee-Na Park (Keimyung University Dongsan Hospital) Ji Sun Lim (Keimyung University Dongsan Hospital) Hye Suk Baek (Keimyung University) Shin Kim (Keimyung University) Hae Won Kim (Keimyung University Dongsan Hospital) Jeong-Ho Hong (Keimyung University Dongsan Hospital)
저널정보
계명대학교 자연과학연구소 Quantitative Bio-Science Quantitative Bio-Science Vol.42 No.1
발행연도
2023.5
수록면
9 - 16 (8page)

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초록· 키워드

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Cardiac arrest (CA) is a severe health condition that can lead to significant neurological deficits. While therapeutic hypothermia (TH) has been shown to improve neurological outcomes and survival rates in CA patients, its effect on cognitive impairment is uncertain. In this study, we aimed to investigate the impact of TH on a mouse model of CA-induced cognitive impairment. The model was created by occluding the bilateral common carotid arteries while monitoring the cerebral blood flow with Laser Doppler flowmetry. Nine-week-old male C57BL/6 mice were randomly assigned to one of the three groups: sham, CA, and TH. We performed three distinct behavior tests to evaluate short-term memory, anxiety and exploratory behaviors, and spatial learning and memory function: the Y-maze test, open field test, and the Morris water maze test, respectively. Our findings indicate that the CA group displayed cognitive impairment in all behavior tests compared to the sham group. Although TH tended to improve the spatial motor memory and alleviate anxiety-like behavior in the CA mouse model, it significantly improved the spatial learning and memory function. Overall, these results suggest that TH can enhance cognitive impairment, a typical feature of AD, after CA in mice, although the molecular and biological mechanisms of TH require further investigation.

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ABSTRACT
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
References

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