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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.10
- 수록면
- 578 - 588 (11page)
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초록· 키워드
오류제보하기
Background: Elevated testicular temperature disrupts spermatogenesis and causes infertility. In the present study, the protective effect of enzymatically biotransformed Panax ginseng Meyer by pectinase (GINST) against chronic intermittent heat stress-induced testicular damage in rats was investigated.
Methods: Male SpragueeDawley rats (4 wk old, 60e70 g) were divided into four groups: normal control (NC), heat-stress control (HC), heat-stress plus GINST-100 mg/kg (HG100), and heat-stress plus GINST-200 mg/kg (HG200) treatment groups. Each dose of GINST (100 mg/kg and 200 mg/kg) was mixed separately with a regular pellet diet and was administered orally for 24 wk. For inducing heat stress, rats in the NC group were maintained at 25℃, whereas rats in the HC, HG100, and HG200 groups were exposed to 32 ±1℃ for 2 h daily for 6 mo. At week 25, the testes and serum from each animal were analyzed for various parameters.
Results: Significant (p < 0.01) changes in the sperm kinematic values and blood chemistry panels were observed in the HC group. Furthermore, spermatogenesis-related molecules, sex hormone receptors, and selected antioxidant enzyme expression levels were also altered in the HC group compared to those in the NC group. GINST (HS100 and HS200) administration significantly (p < 0.05) restored these changes when compared with the HC group. For most of the parameters tested, the HG200 group exhibited potent effects compared with those exhibited by the HG100 group.
Conclusion: GINST may be categorized as an important medicinal herb and a potential therapeutic for the treatment of male subfertility or infertility caused by hyperthermia.
Methods: Male SpragueeDawley rats (4 wk old, 60e70 g) were divided into four groups: normal control (NC), heat-stress control (HC), heat-stress plus GINST-100 mg/kg (HG100), and heat-stress plus GINST-200 mg/kg (HG200) treatment groups. Each dose of GINST (100 mg/kg and 200 mg/kg) was mixed separately with a regular pellet diet and was administered orally for 24 wk. For inducing heat stress, rats in the NC group were maintained at 25℃, whereas rats in the HC, HG100, and HG200 groups were exposed to 32 ±1℃ for 2 h daily for 6 mo. At week 25, the testes and serum from each animal were analyzed for various parameters.
Results: Significant (p < 0.01) changes in the sperm kinematic values and blood chemistry panels were observed in the HC group. Furthermore, spermatogenesis-related molecules, sex hormone receptors, and selected antioxidant enzyme expression levels were also altered in the HC group compared to those in the NC group. GINST (HS100 and HS200) administration significantly (p < 0.05) restored these changes when compared with the HC group. For most of the parameters tested, the HG200 group exhibited potent effects compared with those exhibited by the HG100 group.
Conclusion: GINST may be categorized as an important medicinal herb and a potential therapeutic for the treatment of male subfertility or infertility caused by hyperthermia.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (67)
참고문헌 신청
[단행본] - Waites GMH / 1990 / Marshall’s physiology of reproduction / Churchill Livingstone
[학술지(정기간행물)] - Setchell BP / 2001 / Reduction of long-term effects of local heating of the testis by treatment of rats with a GnRH agonist and an anti-androgen / Reproduction 122 : 255 ~ 263
[학술지(정기간행물)] - Moore CR / 1923 / Heat application and testicular degeneration / Anat Rec 26 : 344 ~ 403
[학술지(정기간행물)] - Miranda LA / 2013 / Effects of global warming on fish reproductive endocrine axis, with special emphasis in pejerrey Odontesthes bonariensis / Gen Comp Endocrinol 192 : 45 ~ 54
[학술지(정기간행물)] - Baranski B / 1993 / Effects of the workplace on fertility and related reproductive outcomes / Environ Health Perspect 101 : 81 ~ 90
[학술지(정기간행물)] - Setchell BP / 2001 / Reduction of long-term effects of local heating of the testis by treatment of rats with a GnRH agonist and an anti-androgen / Reproduction 122 : 255 ~ 263
[학술지(정기간행물)] - Moore CR / 1923 / Heat application and testicular degeneration / Anat Rec 26 : 344 ~ 403
[학술지(정기간행물)] - Miranda LA / 2013 / Effects of global warming on fish reproductive endocrine axis, with special emphasis in pejerrey Odontesthes bonariensis / Gen Comp Endocrinol 192 : 45 ~ 54
[학술지(정기간행물)] - Baranski B / 1993 / Effects of the workplace on fertility and related reproductive outcomes / Environ Health Perspect 101 : 81 ~ 90
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UCI(KEPA) : I410-ECN-0101-2018-524-001599362