지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 125 - 134 (10page)
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초록· 키워드
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Background: Excessive stress causes varied physiological and psychological disorders including male reproductive problems. Here, we attempted to investigate the protective effects of Korean Red Ginseng (Panax ginseng Meyer; KRG) against sub-acute immobilization stress-induced testicular damage in experimental rats.
Methods: Male rats (age, 4 wk; weight, 60-70 g) were divided into four groups (n = 8 in each group): normal control group, immobilization control group, immobilization group treated with 100 mg/kg of KRG daily, and immobilization group treated with 200 mg/kg of KRG daily. Normal control and immobilization control groups received vehicle only. KRG (100 mg/kg and 200 mg/kg) was mixed in the standard diet powder and fed daily for 6 mo. Parameters such as organ weight, blood chemistry, sperm kinematic values, and expression levels of testicular-related molecules were measured using commercially available kits, Western blotting, and reverse transcription polymerase chain reaction.
Results: Data revealed that KRG restored the altered testis and epididymis weight in immobilization stress-induced rats significantly (p < 0.05). Further, KRG ameliorated the altered blood chemistry and sperm kinematic values when compared with the immobilization control group and attenuated the altered expression levels of spermatogenesis-related proteins (nectin-2, cAMP responsive element binding protein 1, and inhibin-⍺), sex hormone receptors (androgen receptor, luteinizing hormone receptor, and follicle-stimulating hormone receptor), and antioxidant-related enzymes (glutathione Stransferase m5, peroxiredoxin-4, and glutathione peroxidase 4) significantly in the testes of immobilization stress-induced rats.
Conclusion: KRG protected immobilization stress-induced testicular damage and fertility factors in rats, thereby indicating its potential in the treatment of stress-related male sterility.
Methods: Male rats (age, 4 wk; weight, 60-70 g) were divided into four groups (n = 8 in each group): normal control group, immobilization control group, immobilization group treated with 100 mg/kg of KRG daily, and immobilization group treated with 200 mg/kg of KRG daily. Normal control and immobilization control groups received vehicle only. KRG (100 mg/kg and 200 mg/kg) was mixed in the standard diet powder and fed daily for 6 mo. Parameters such as organ weight, blood chemistry, sperm kinematic values, and expression levels of testicular-related molecules were measured using commercially available kits, Western blotting, and reverse transcription polymerase chain reaction.
Results: Data revealed that KRG restored the altered testis and epididymis weight in immobilization stress-induced rats significantly (p < 0.05). Further, KRG ameliorated the altered blood chemistry and sperm kinematic values when compared with the immobilization control group and attenuated the altered expression levels of spermatogenesis-related proteins (nectin-2, cAMP responsive element binding protein 1, and inhibin-⍺), sex hormone receptors (androgen receptor, luteinizing hormone receptor, and follicle-stimulating hormone receptor), and antioxidant-related enzymes (glutathione Stransferase m5, peroxiredoxin-4, and glutathione peroxidase 4) significantly in the testes of immobilization stress-induced rats.
Conclusion: KRG protected immobilization stress-induced testicular damage and fertility factors in rats, thereby indicating its potential in the treatment of stress-related male sterility.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (47)
참고문헌 신청
Cocuzza M / 2007 / Clinical relevance of oxidative stress and sperm chromatin damage in male infertility : an evidence based analysis / International Braz J Urol 33:603~621
Brotman DJ / 2007 / The cardiovascular toll of stress / Lancet 370:1089~1100
Rosmond R / 1998 / Stress-related cortisol secretion in men : relationships with abdominal obesity and endocrine, metabolic and hemodynamic abnormalities / J Clin Endocrinol Metab 83:1853~1859
Nargund VH / 2015 / Effects of psychological stress on male fertility / Nature Reviews Urology 12:373~382
Kirby ED / 2009 / Stress increases putative gonadotropin inhibitory hormone and decreases luteinizing hormone in male rats / Proc Natl Acad Sci U.S.A 106:11324~11329
Brotman DJ / 2007 / The cardiovascular toll of stress / Lancet 370:1089~1100
Rosmond R / 1998 / Stress-related cortisol secretion in men : relationships with abdominal obesity and endocrine, metabolic and hemodynamic abnormalities / J Clin Endocrinol Metab 83:1853~1859
Nargund VH / 2015 / Effects of psychological stress on male fertility / Nature Reviews Urology 12:373~382
Kirby ED / 2009 / Stress increases putative gonadotropin inhibitory hormone and decreases luteinizing hormone in male rats / Proc Natl Acad Sci U.S.A 106:11324~11329
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UCI(KEPA) : I410-ECN-0101-2019-524-000425207