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논문 기본 정보

자료유형
학술저널
저자정보
Jin Kyeong Kim (Sungkyunkwan University) Kon Kuk Shin (Sungkyunkwan University) Haeyeop Kim (Sungkyunkwan University) Yo Han Hong (Sungkyunkwan University) Wooram Choi (Sungkyunkwan University) Yi-Seong Kwak (Korea Ginseng Corporation) Chang-Kyun Han (Korea Ginseng Corporation) Sun Hee Hyun (Korea Ginseng Corporation) Jae Youl Cho (Sungkyunkwan University)
저널정보
고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.45 No.6
발행연도
2021.11
수록면
717 - 725 (9page)

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초록· 키워드

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Background: Korean Red Ginseng (KRG) is a traditional herb that has several beneficial properties including anti-aging, anti-inflammatory, and autophagy regulatory effects. However, the mechanisms of these effects are not well understood. In this report, the underlying mechanisms of anti-inflammatory and autophagy-promoting effects were investigated in aged mice treated with KRG-water extract (WE) over a long period.
Methods: The mechanisms of anti-inflammatory and autophagy-promoting activities of KRG-WE were evaluated in kidney, lung, liver, stomach, and colon of aged mice using semi-quantitative reverse transcription polymerase chain reaction (RT-PCR), quantitative RT-PCR (qRT-PCR), and western blot analysis.
Results: KRG-WE significantly suppressed the mRNA expression levels of inflammation-related genes such as interleukin (IL)-1β, IL-8, tumor necrosis factor (TNF)-α, monocyte chemoattractant protein-1 (MCP-1), and IL-6 in kidney, lung, liver, stomach, and colon of the aged mice. Furthermore, KRG-WE downregulated the expression of transcription factors and their protein levels associated with inflammation in lung and kidney of aged mice. KRG-WE also increased the expression of autophagy-related genes and their protein levels in colon, liver, and stomach.
Conclusion: The results suggest that KRG can suppress inflammatory responses and recover autophagy activity in aged mice.

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ABSTRACT
1. Introduction
2. Materials and methods
3. Results and discussion
4. Conclusion
References

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