지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.10
- 수록면
- 676 - 683 (8page)
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초록· 키워드
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Background: Korean Red Ginseng (KRG) is widely used for strengthening the immune system and fighting fatigue, especially in people with deficiency syndrome. However, there is concern that the long-term application or a high dose of KRG can cause “fireness” (上火 in Chinese) because of its “dryness” (燥性 in Chinese). The aim of this study was to assess the safety and efficacy of a 4-week treatment with KRG in participants with deficiency syndrome.
Methods: This was a 4-week, randomized, double-blind, placebo-controlled clinical trial. A total of 180 Chinese participants were randomly allocated to three groups: placebo control group, participants were given a placebo, 3.6 g/d; KRG 1.8 g and 3.6 g groups. The primary outcomes were the changes in fireness and safety evaluation (adverse events, laboratory tests, and electrocardiogram). The secondary outcomes were the efficacy of KRG on fatigue, which include the following: traditional Chinese medicine (TCM) symptom scale and fatigue self-assessment scale.
Results: Of the 180 patients, 174 completed the full study. After 4 weeks of KRG treatment, the Fire-heat symptoms score including Excess fire-heat score and Deficient fire-heat score showed no significant change as compared with placebo treatment, and no clinically significant changes in any safety parameter were observed. Based on the TCM syndrome score and fatigue self-assessment score, TCM symptoms and fatigue were greatly improved after treatment with KRG, which showed a dose- and time-dependent effect. The total effective rate was also significantly increased in the KRG groups.
Conclusion: Our study revealed that KRG has a potent antifatigue effect without significant adverse effects in people with deficiency syndrome. Although a larger sample size and longer treatment may be required for a more definite conclusion, this clinical trial is the first to disprove the common conception of “fireness” related to KRG.
Methods: This was a 4-week, randomized, double-blind, placebo-controlled clinical trial. A total of 180 Chinese participants were randomly allocated to three groups: placebo control group, participants were given a placebo, 3.6 g/d; KRG 1.8 g and 3.6 g groups. The primary outcomes were the changes in fireness and safety evaluation (adverse events, laboratory tests, and electrocardiogram). The secondary outcomes were the efficacy of KRG on fatigue, which include the following: traditional Chinese medicine (TCM) symptom scale and fatigue self-assessment scale.
Results: Of the 180 patients, 174 completed the full study. After 4 weeks of KRG treatment, the Fire-heat symptoms score including Excess fire-heat score and Deficient fire-heat score showed no significant change as compared with placebo treatment, and no clinically significant changes in any safety parameter were observed. Based on the TCM syndrome score and fatigue self-assessment score, TCM symptoms and fatigue were greatly improved after treatment with KRG, which showed a dose- and time-dependent effect. The total effective rate was also significantly increased in the KRG groups.
Conclusion: Our study revealed that KRG has a potent antifatigue effect without significant adverse effects in people with deficiency syndrome. Although a larger sample size and longer treatment may be required for a more definite conclusion, this clinical trial is the first to disprove the common conception of “fireness” related to KRG.
목차
ABSTRACT
1. Introduction
2. Methods
3. Results
4. Discussion
References
참고문헌 (38)
참고문헌 신청
Choi KT / 2008 / Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer / Acta Pharmacol Sin 29:1109~1118
강수원 / 2012 / Ginseng, the 'Immunity Boost': The Effects of Panax ginseng on Immune System / Journal of Ginseng Research 36(4):354~368
Hofseth LJ / 2007 / Inflammation, cancer, and targets of ginseng / J Nutr 137:183s~185s
Dal-Sik Kim / 2016 / Effect of Red Ginseng on cytochrome P450 and P-glycoprotein activities in healthy volunteers / Journal of Ginseng Research 40(4):375~381
공병만 / 2008 / 백삼, 발효인삼, 홍삼 농축액의 이화학적 특성 / Journal of Ginseng Research 32(3):238~243
강수원 / 2012 / Ginseng, the 'Immunity Boost': The Effects of Panax ginseng on Immune System / Journal of Ginseng Research 36(4):354~368
Hofseth LJ / 2007 / Inflammation, cancer, and targets of ginseng / J Nutr 137:183s~185s
Dal-Sik Kim / 2016 / Effect of Red Ginseng on cytochrome P450 and P-glycoprotein activities in healthy volunteers / Journal of Ginseng Research 40(4):375~381
공병만 / 2008 / 백삼, 발효인삼, 홍삼 농축액의 이화학적 특성 / Journal of Ginseng Research 32(3):238~243
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UCI(KEPA) : I410-ECN-0101-2020-524-000504753