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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.6
- 수록면
- 370 - 378 (9page)
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초록· 키워드
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Background: Ginseng has been the subject of many experimental and clinical studies to uncover the diverse biological activities of its constituent compounds. It is a traditional medicine that has been used for its immunostimulatory, antithrombotic, antioxidative, anti-inflammatory, and anticancer effects. Ginseng may interact with concomitant medications and alter metabolism and/or drug transport, which may alter the known efficacy and safety of a drug; thus, the role of ginseng may be controversial when taken with other medications.
Methods: We extensively assessed the effects of Korean Red Ginseng (KRG) in rats on the expression of enzymes responsible for drug metabolism [cytochrome p450 (CYP)] and transporters [multiple drug resistance (MDR) and organic anion transporter (OAT)] in vitro and on the pharmacokinetics of two probe drugs, midazolam and fexofenadine, after a 2-wk repeated administration of KRG at different doses.
Results: The results showed that 30 mg/kg KRG significantly increased the expression level of CYP3A11 protein in the liver and 100 mg/kg KRG increased both the mRNA and protein expression of OAT1 in the kidney. Additionally, KRG significantly increased the mRNA and protein expression of OAT1, OAT3, and MDR1 in the liver. Although there were no significant changes in the metabolism of midazolam to its major metabolite, 1"-hydroxymidazolam, KRG significantly decreased the systemic exposure of fexofenadine in a dose-dependent manner.
Conclusion: Because KRG is used as a health supplement, there is a risk of KRG overdose; thus, a clinical trial of high doses would be useful. The use of KRG in combination with P-glycoprotein substrate drugs should also be carefully monitored.
Methods: We extensively assessed the effects of Korean Red Ginseng (KRG) in rats on the expression of enzymes responsible for drug metabolism [cytochrome p450 (CYP)] and transporters [multiple drug resistance (MDR) and organic anion transporter (OAT)] in vitro and on the pharmacokinetics of two probe drugs, midazolam and fexofenadine, after a 2-wk repeated administration of KRG at different doses.
Results: The results showed that 30 mg/kg KRG significantly increased the expression level of CYP3A11 protein in the liver and 100 mg/kg KRG increased both the mRNA and protein expression of OAT1 in the kidney. Additionally, KRG significantly increased the mRNA and protein expression of OAT1, OAT3, and MDR1 in the liver. Although there were no significant changes in the metabolism of midazolam to its major metabolite, 1"-hydroxymidazolam, KRG significantly decreased the systemic exposure of fexofenadine in a dose-dependent manner.
Conclusion: Because KRG is used as a health supplement, there is a risk of KRG overdose; thus, a clinical trial of high doses would be useful. The use of KRG in combination with P-glycoprotein substrate drugs should also be carefully monitored.
목차
ABSTRACT
1. Introduction
2. Methods
3. Results
4. Discussion
5. Conclusion
References
참고문헌 (54)
참고문헌 신청
[학술지(정기간행물)] - Helms S / 2004 / Cancer prevention and therapeutics: Panax ginseng / Altern Med Rev 9 : 259 ~ 274
[학술지(정기간행물)] - Christensen LP / 2009 / Ginsenosides chemistry, biosynthesis, analysis, and potential health effects / Adv Food Nutr Res 55 : 1 ~ 99
[학술지(정기간행물)] - Choi SS / 2003 / Effect of ginsenosides administered intrathecally on the antinociception induced by cold water swimming stress in the mouse / Biol Pharm Bull 26 : 858 ~ 861
[학술지(정기간행물)] - Deyama T / 2001 / Constituents and pharmacological effects of Eucommia and Siberian ginseng / Acta Pharmacol Sin 22 : 1057 ~ 1070
[학술지(정기간행물)] - Liao BS / 2002 / Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons in vitro / Exp Neurol 173 : 224 ~ 234
[학술지(정기간행물)] - Christensen LP / 2009 / Ginsenosides chemistry, biosynthesis, analysis, and potential health effects / Adv Food Nutr Res 55 : 1 ~ 99
[학술지(정기간행물)] - Choi SS / 2003 / Effect of ginsenosides administered intrathecally on the antinociception induced by cold water swimming stress in the mouse / Biol Pharm Bull 26 : 858 ~ 861
[학술지(정기간행물)] - Deyama T / 2001 / Constituents and pharmacological effects of Eucommia and Siberian ginseng / Acta Pharmacol Sin 22 : 1057 ~ 1070
[학술지(정기간행물)] - Liao BS / 2002 / Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons in vitro / Exp Neurol 173 : 224 ~ 234
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UCI(KEPA) : I410-ECN-0101-2018-524-003161266