지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.10
- 수록면
- 431 - 436 (6page)
이용수
초록· 키워드
오류제보하기
Background: Although numerous studies of the anticancer activities of Korean Red Ginseng (KRG) have been performed, the therapeutic effect of KRG on leukemia has not been fully elucidated. In this study, we investigated the antileukemia activities of KRG and its cellular and molecular mechanisms.
Methods: An established leukemia tumor model induced by xenografted T cell lymphoma (RMA cells) was used to test the therapeutic activity of KRG water extract (KRG-WE). Direct cytotoxic activity of KRG-WE was confirmed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The immunomodulatory activities of KRG-WE were verified by immunohistochemistry, nitric oxide production assay. The inhibitory effect of KRG-WE on cell survival signaling was also examined.
Results: Orally administered KRG-WE reduced the sizes of tumor masses. Levels of apoptosis regulatory enzymes and cleaved forms of caspases-3 and -8 were increased by this extract. In addition, expression of matrix metalloproteinase-9, a metastasis regulatory enzyme, was decreased by KRG-WE treatment. The proportion of CD11cþ cells was remarkably increased in the KRG-treated group compared to the control group. However, KRG-WE did not show significant direct cytotoxicity against RMA cells.
Conclusion: Our results strongly suggest that the KRG might have antileukemia activity through CD11cþ cell-mediated antitumor immunity.
Methods: An established leukemia tumor model induced by xenografted T cell lymphoma (RMA cells) was used to test the therapeutic activity of KRG water extract (KRG-WE). Direct cytotoxic activity of KRG-WE was confirmed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The immunomodulatory activities of KRG-WE were verified by immunohistochemistry, nitric oxide production assay. The inhibitory effect of KRG-WE on cell survival signaling was also examined.
Results: Orally administered KRG-WE reduced the sizes of tumor masses. Levels of apoptosis regulatory enzymes and cleaved forms of caspases-3 and -8 were increased by this extract. In addition, expression of matrix metalloproteinase-9, a metastasis regulatory enzyme, was decreased by KRG-WE treatment. The proportion of CD11cþ cells was remarkably increased in the KRG-treated group compared to the control group. However, KRG-WE did not show significant direct cytotoxicity against RMA cells.
Conclusion: Our results strongly suggest that the KRG might have antileukemia activity through CD11cþ cell-mediated antitumor immunity.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results and discussion
References
참고문헌 (42)
참고문헌 신청
[학술지(정기간행물)] - Xiaoguang C / 1998 / Cancer chemopreventive and therapeutic activities of red ginseng / Ethnopharmacol 60 : 71 ~ 78
[학술지(정기간행물)] - Kim JH / 2005 / Effect of crude saponin of Korean Red Ginseng on high-fat diet-induced obesity in the rat / J Pharmacol Sci 97 : 124 ~ 131
[학술지(정기간행물)] - Shin-Jung Kim / 2015 / Anti-breast cancer activity of Fine Black ginseng (Panax ginseng Meyer) and ginsenoside Rg5 / Journal of Ginseng Research 39 (2) : 125 ~ 134
[학술지(정기간행물)] - Seyed Fazel Nabavi / 2015 / Ginsenoside Rd and ischemic stroke; a short review of literatures / Journal of Ginseng Research 39 (4) : 299 ~ 303
[학술지(정기간행물)] - 강수원 / 2012 / Ginseng, the 'Immunity Boost': The Effects of Panax ginseng on Immune System / Journal of Ginseng Research 36 (4) : 354 ~ 368
[학술지(정기간행물)] - Kim JH / 2005 / Effect of crude saponin of Korean Red Ginseng on high-fat diet-induced obesity in the rat / J Pharmacol Sci 97 : 124 ~ 131
[학술지(정기간행물)] - Shin-Jung Kim / 2015 / Anti-breast cancer activity of Fine Black ginseng (Panax ginseng Meyer) and ginsenoside Rg5 / Journal of Ginseng Research 39 (2) : 125 ~ 134
[학술지(정기간행물)] - Seyed Fazel Nabavi / 2015 / Ginsenoside Rd and ischemic stroke; a short review of literatures / Journal of Ginseng Research 39 (4) : 299 ~ 303
[학술지(정기간행물)] - 강수원 / 2012 / Ginseng, the 'Immunity Boost': The Effects of Panax ginseng on Immune System / Journal of Ginseng Research 36 (4) : 354 ~ 368
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UCI(KEPA) : I410-ECN-0101-2018-524-001598572