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논문 기본 정보

자료유형
학술저널
저자정보
Jae Gwang Park (Sungkyunkwan University) Young-Jin Son (Sunchon National University) Adithan Aravinthan (Chonbuk National University) Jong-Hoon Kim (Chonbuk National University) Jae Youl Cho (Sungkyunkwan University)
저널정보
고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.40 No.4
발행연도
2016.10
수록면
431 - 436 (6page)

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초록· 키워드

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Background: Although numerous studies of the anticancer activities of Korean Red Ginseng (KRG) have been performed, the therapeutic effect of KRG on leukemia has not been fully elucidated. In this study, we investigated the antileukemia activities of KRG and its cellular and molecular mechanisms.
Methods: An established leukemia tumor model induced by xenografted T cell lymphoma (RMA cells) was used to test the therapeutic activity of KRG water extract (KRG-WE). Direct cytotoxic activity of KRG-WE was confirmed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The immunomodulatory activities of KRG-WE were verified by immunohistochemistry, nitric oxide production assay. The inhibitory effect of KRG-WE on cell survival signaling was also examined.
Results: Orally administered KRG-WE reduced the sizes of tumor masses. Levels of apoptosis regulatory enzymes and cleaved forms of caspases-3 and -8 were increased by this extract. In addition, expression of matrix metalloproteinase-9, a metastasis regulatory enzyme, was decreased by KRG-WE treatment. The proportion of CD11cþ cells was remarkably increased in the KRG-treated group compared to the control group. However, KRG-WE did not show significant direct cytotoxicity against RMA cells.
Conclusion: Our results strongly suggest that the KRG might have antileukemia activity through CD11cþ cell-mediated antitumor immunity.

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ABSTRACT
1. Introduction
2. Materials and methods
3. Results and discussion
References

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