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논문 기본 정보

자료유형
학술저널
저자정보
Dongsoo Kim (Pusan National University) Sunoh Kwon (Korea Institute of Oriental Medicine) Hyongjun Jeon (Pusan National University) Sun Ryu (Pusan National University) Ki-Tae Ha (Pusan National University) Seungtae Kim (Pusan National University)
저널정보
고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.42 No.4
발행연도
2018.10
수록면
429 - 435 (7page)

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초록· 키워드

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Background: Recent studies have shown that Korean Red Ginseng (KRG) successfully protects against dopaminergic neuronal death in the nigrostriatal pathway of a Parkinson’s disease (PD) mouse model induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration; however, the mechanism has yet to be identified. Therefore, in this study we used two-dimensional electrophoresis to investigate the effects of KRG on the changes in protein expression in the substantia nigra (SN) of MPTPtreated mice.
Methods: Male C57BL/6 mice (9 wk old) were intraperitoneally administered MPTP (20 mg/kg) four times at 2-h intervals, after which KRG (100 mg/kg) was orally administered once a day for 5 d. Two hours after the fifth KRG administration, a pole test was conducted to evaluate motor function, after which the brains were immediately collected. Survival of dopaminergic neurons was measured by immunohistochemistry, and protein expression was measured by two-dimensional electrophoresis and Western blotting.
Results: KRG alleviated MPTP-induced behavioral dysfunction and neuronal toxicity in the SN. Additionally, the expression of eight proteins related to neuronal formation and energy metabolism for survival were shown to have changed significantly in response to MPTP treatment or KRG administration. KRG alleviated the downregulated protein expression following MPTP administration, indicating that it may enhance neuronal development and survival in the SN of MPTP-treated mice.
Conclusion: These findings indicate that KRG may have therapeutic potential for the treatment of patients with PD.

목차

abstract
1. Introduction
2. Materials and methods
3. Results
4. Discussion
5. Conclusion
References

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