개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.3
- 수록면
- 254 - 263 (10page)
이용수
초록· 키워드
오류제보하기
Background: A chronic social defeat stress (CSDS) model has been proposed as relevant to stress-induced behavioral change in humans. In this study, we examined the effect of Korean Red Ginseng (KRG) on CSDS-induced mood disorders and protein expression in an animal model.
Methods: To evaluate the effect of KRG on social defeat stress, test mice were exposed in the resident aggressor’s home cage compartment for 14 days beginning 1 h after KRG treatment (10, 20, and 40 ㎎/㎏, per oral (p.o.)). After the exposure, behavioral tests to measure anxiety, social interaction, and depression-like behavior were performed. To investigate the underlying mechanism, N-methyl-D-aspartate receptor expression levels in CSDS-induced mice were evaluated using Western blot analysis.
Results: CSDS induced anxiety-like behaviors by decreasing central activity in the open-field test and open-arm approach in the elevated plus maze test and led to social avoidance behavior in the social interaction test. CSDS mice showed upregulated NR1, NR2A, and NR2B expression in the hippocampus. KRG 20 and 40 ㎎/㎏ ameliorated anxiety-like activities and KRG 20 ㎎/㎏ alleviated social avoidance by decreasing time in the corner zone. KRG treatment recovered CSDS-induced NR1, NR2A, and NR2B protein levels in the hippocampus.
Conclusion: These results indicate that KRG has a therapeutic effect on CSDS-induced mood disorder by alleviating N-methyl-D-aspartate receptor overexpression in the hippocampus.
Methods: To evaluate the effect of KRG on social defeat stress, test mice were exposed in the resident aggressor’s home cage compartment for 14 days beginning 1 h after KRG treatment (10, 20, and 40 ㎎/㎏, per oral (p.o.)). After the exposure, behavioral tests to measure anxiety, social interaction, and depression-like behavior were performed. To investigate the underlying mechanism, N-methyl-D-aspartate receptor expression levels in CSDS-induced mice were evaluated using Western blot analysis.
Results: CSDS induced anxiety-like behaviors by decreasing central activity in the open-field test and open-arm approach in the elevated plus maze test and led to social avoidance behavior in the social interaction test. CSDS mice showed upregulated NR1, NR2A, and NR2B expression in the hippocampus. KRG 20 and 40 ㎎/㎏ ameliorated anxiety-like activities and KRG 20 ㎎/㎏ alleviated social avoidance by decreasing time in the corner zone. KRG treatment recovered CSDS-induced NR1, NR2A, and NR2B protein levels in the hippocampus.
Conclusion: These results indicate that KRG has a therapeutic effect on CSDS-induced mood disorder by alleviating N-methyl-D-aspartate receptor overexpression in the hippocampus.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Korean Red Ginseng prevents posttraumatic stress disorder-triggered depression-like behaviors in rats via activation of the serotonergic system
Journal of Ginseng Research
2020 .07
-
Neuroprotective effect of Korean Red Ginseng against single prolonged stress-induced memory impairments and inflammation in the rat brain associated with BDNF expression
Journal of Ginseng Research
2022 .05
-
The effects of Korean Red Ginseng on stress-related neurotransmitters and gene expression: A randomized, double-blind, placebo-controlled trial
Journal of Ginseng Research
2023 .11
-
Korean Red Ginseng extract attenuates alcohol-induced addictive responses and cognitive impairments by alleviating neuroinflammation
Journal of Ginseng Research
2023 .07
-
Effect of Korean Red Ginseng extracts on drug-drug interactions
Journal of Ginseng Research
2018 .06
-
Korean Red Ginseng water extract arrests growth of xenografted lymphoma cells
Journal of Ginseng Research
2016 .10
-
Protective effects of KRG against renal injury in aged mice
한국실험동물학회 학술발표대회 논문집
2025 .02
-
Proteomic change by Korean Red Ginseng in the substantia nigra of a Parkinson’s disease mouse model
Journal of Ginseng Research
2018 .10
-
Korean Red Ginseng exerts anti-inflammatory and autophagypromoting activities in aged mice
Journal of Ginseng Research
2021 .11
-
Proteomic studies of putative molecular signatures for biological effects by Korean Red Ginseng
Journal of Ginseng Research
2019 .10
-
Korean red ginseng excitation of paraventricular nucleus neurons via non-N-methyl-D-aspartate glutamate receptor activation in mice
Journal of Veterinary Science
2018 .03
-
Anti-aging effects of Korean Red Ginseng (KRG) in differentiated embryo chondrocyte (DEC) knockout mice
Journal of Ginseng Research
2021 .01
-
Korean Red Ginseng water extract inhibits cadmium-induced lung injury via suppressing MAPK/ERK1/2/AP-1 pathway
Journal of Ginseng Research
2022 .09
-
Korean Red Ginseng enhances cardiac hemodynamics on doxorubicin-induced toxicity in rats
Journal of Ginseng Research
2020 .05
-
Safety and antifatigue effect of Korean Red Ginseng: a randomized, double-blind, and placebo-controlled clinical trial
Journal of Ginseng Research
2019 .10
-
KRG and its major ginsenosides do not show distinct steroidogenic activities examined by the OECD test guideline 440 and 456 assays
Journal of Ginseng Research
2023 .05
-
Korean Red Ginseng alleviates dextran sodium sulfate-induced colitis through gut microbiota modulation in mice
Journal of Ginseng Research
2024 .11
-
Immuno-enhancement effects of Korean Red Ginseng in healthy adults: a randomized, double-blind, placebo-controlled trial
Journal of Ginseng Research
2021 .01
-
The Effect of Korean Red Ginseng on Symptoms and Quality of Life in Chronic Tinnitus: A Randomized, Open-Label Pilot Study
Journal of Audiology & Otology
2015 .01
-
Effect of Korean Red Ginseng treatment on the gene expression profile of diabetic rat retina
Journal of Ginseng Research
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0