지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.10
- 수록면
- 615 - 619 (5page)
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초록· 키워드
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Background: Black ginseng has a more potent biological activity than non-steamed ginseng. We investigated the effects of long-term intake of dietary black ginseng extract (BG) on antioxidant activity in aged mice. We also compared the effects of BG on cognitive deficits with those of white ginseng extract (WG) and red ginseng extract (RG).
Methods: Ten-month-old mice were fed an AIN-93G-based diet containing 10 g/kg (low dose, L) or 30 g/kg (high dose, H) WG powder, RG powder, or BG powder for 24 wk. We measured serum lipids, the activities of antioxidant enzymes, and malondialdehyde levels. Additionally, the protein expression levels of choline acetyltransferase and vesicular acetylcholine transporter, which are presynaptic cholinergic markers in the cortex and hippocampus of the brain, were measured by western blotting.
Results: Triglyceride levels were reduced in all the extract-treated mice, except those in the LBG group. High-density lipoprotein cholesterol levels in the HBG group were higher than those in the control group. Total cholesterol levels were reduced in the LBG group. Additionally, glucose levels in the HBG group were significantly reduced by 41.2%. There were lower levels of malondialdehyde in the LBG group than in the control group. Furthermore, glutathione reductase activity increased in the HWG group and the HRG group. The protein expression levels of choline acetyltransferase and vesicular acetylcholine transporter significantly increased in all the ginseng-treated groups.
Conclusion: The results suggest that supplementation with the tested ginseng extracts may suppress the cognitive decline associated with aging, via regulation of the cholinergic and antioxidant defense
Methods: Ten-month-old mice were fed an AIN-93G-based diet containing 10 g/kg (low dose, L) or 30 g/kg (high dose, H) WG powder, RG powder, or BG powder for 24 wk. We measured serum lipids, the activities of antioxidant enzymes, and malondialdehyde levels. Additionally, the protein expression levels of choline acetyltransferase and vesicular acetylcholine transporter, which are presynaptic cholinergic markers in the cortex and hippocampus of the brain, were measured by western blotting.
Results: Triglyceride levels were reduced in all the extract-treated mice, except those in the LBG group. High-density lipoprotein cholesterol levels in the HBG group were higher than those in the control group. Total cholesterol levels were reduced in the LBG group. Additionally, glucose levels in the HBG group were significantly reduced by 41.2%. There were lower levels of malondialdehyde in the LBG group than in the control group. Furthermore, glutathione reductase activity increased in the HWG group and the HRG group. The protein expression levels of choline acetyltransferase and vesicular acetylcholine transporter significantly increased in all the ginseng-treated groups.
Conclusion: The results suggest that supplementation with the tested ginseng extracts may suppress the cognitive decline associated with aging, via regulation of the cholinergic and antioxidant defense
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results and discussion
References
참고문헌 (41)
참고문헌 신청
[학술지(정기간행물)] - Osiewacz HD / 1997 / DNA reorganization and biological aging. A review / Biochemistry (Mosc) 62 : 1275 ~ 1284
[학술지(정기간행물)] - Seo AY / 2010 / New insights into the role of mitochondria in aging : mitochondrial dynamics and more / J Cell Sci 123 : 2533 ~ 2542
[학술지(정기간행물)] - Harman D / 1956 / Aging : a theory based on free radical and radiation chemistry / J Gerontol 11 : 298 ~ 300
[학술지(정기간행물)] - Berry A / 2008 / Deletion of the lifespan determinant p66(Shc) improves performance in a spatial memory task, decreases levels of oxidative stress markers in the hippocampus and increases levels of the neurotrophin BDNF in adult mice / Exp Gerontol 43 : 200 ~ 208
[학술지(정기간행물)] - Duffy KB / 2008 / A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats / Neurobiol Aging 29 : 1680 ~ 1689
[학술지(정기간행물)] - Seo AY / 2010 / New insights into the role of mitochondria in aging : mitochondrial dynamics and more / J Cell Sci 123 : 2533 ~ 2542
[학술지(정기간행물)] - Harman D / 1956 / Aging : a theory based on free radical and radiation chemistry / J Gerontol 11 : 298 ~ 300
[학술지(정기간행물)] - Berry A / 2008 / Deletion of the lifespan determinant p66(Shc) improves performance in a spatial memory task, decreases levels of oxidative stress markers in the hippocampus and increases levels of the neurotrophin BDNF in adult mice / Exp Gerontol 43 : 200 ~ 208
[학술지(정기간행물)] - Duffy KB / 2008 / A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats / Neurobiol Aging 29 : 1680 ~ 1689
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UCI(KEPA) : I410-ECN-0101-2018-524-001599413