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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.10
- 수록면
- 577 - 584 (8page)
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초록· 키워드
오류제보하기
Background: Ginseng (Panax ginseng) is a widely used traditional herbal supplement that possesses various health-enhancing efficacies. Various ginseng products are available in market, especially in the Korean peninsula, in the form of drinks, tablets, and capsules. The different ginseng types include the traditional red ginseng extract (RGE), white ginseng, and black red ginseng extract (BRGE). Their fermented and enzyme-treated products are also available. Different treatment regimens alter the bioavailability of certain compounds present in the respective ginseng extracts. Therefore, in this study, we aimed to compare the antioxidant and immune-stimulating activities of RGE, BRGE, and fermented red ginseng extract (FRGE).
Methods: We used an acetaminophen-induced oxidative stress model for investigating the reduction of oxidative stress by RGE, BRGE, and FRGE in Sprague Dawley rats. A cyclophosphamide-induced immunosuppression model was used to evaluate the immune-stimulating activities of these ginseng extracts in BALB/c mice.
Results: Our results showed that most prominently, RGE (in almost all experiments) exhibited excellent antioxidant effects via increasing superoxide dismutase, catalase, and glutathione peroxidase activities in the liver and decreasing serum 8-hydroxy-20-deoxyguanosine, aspartate aminotransferase, and lactate dehydrogenase levels compared with the groups treated with FRGE and BRGE. Moreover, RGE significantly increased the number of white blood cells, especially T and B lymphocytes, and antibody-forming cells in the spleen and thymus, and it also activated a number of immune cell subtypes.
Conclusion: Taken together, these results indicate that RGE is the best supplement for consumption in everyday life for overall health-enhancing properties.
Methods: We used an acetaminophen-induced oxidative stress model for investigating the reduction of oxidative stress by RGE, BRGE, and FRGE in Sprague Dawley rats. A cyclophosphamide-induced immunosuppression model was used to evaluate the immune-stimulating activities of these ginseng extracts in BALB/c mice.
Results: Our results showed that most prominently, RGE (in almost all experiments) exhibited excellent antioxidant effects via increasing superoxide dismutase, catalase, and glutathione peroxidase activities in the liver and decreasing serum 8-hydroxy-20-deoxyguanosine, aspartate aminotransferase, and lactate dehydrogenase levels compared with the groups treated with FRGE and BRGE. Moreover, RGE significantly increased the number of white blood cells, especially T and B lymphocytes, and antibody-forming cells in the spleen and thymus, and it also activated a number of immune cell subtypes.
Conclusion: Taken together, these results indicate that RGE is the best supplement for consumption in everyday life for overall health-enhancing properties.
목차
abstract
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (54)
참고문헌 신청
[학술지(정기간행물)] - Patel S / 2017 / Adaptogenic herb ginseng (Panax) as medical food: status quo and future prospects / Biomedicine & Pharmacotherapy 85 : 120 ~ 127
[학술지(정기간행물)] - Dai D / 2017 / Ginseng on cancer: potential role in modulating inflammation-mediated angiogenesis / Am J Chin Med 45 : 13 ~ 22
[학술지(정기간행물)] - Qian J / 2015 / Active ingredients and its pharmacokinetic behavior and anti-inflammatory effects of ginseng with different steamed times / Zhongguo Zhong Yao Za Zhi 40 : 3770 ~ 3774
[학술지(정기간행물)] - Yuan SM / 2015 / Potential cardioprotective effects of Ginseng preparations / Pak J Pharm Sci 28 : 963 ~ 968
[학술지(정기간행물)] - Park J / 1996 / Recent studies on the chemical constituents of Korean ginseng (Panax ginseng CA Meyer) / Korean J Ginseng Sci 20 : 389 ~ 415
[학술지(정기간행물)] - Dai D / 2017 / Ginseng on cancer: potential role in modulating inflammation-mediated angiogenesis / Am J Chin Med 45 : 13 ~ 22
[학술지(정기간행물)] - Qian J / 2015 / Active ingredients and its pharmacokinetic behavior and anti-inflammatory effects of ginseng with different steamed times / Zhongguo Zhong Yao Za Zhi 40 : 3770 ~ 3774
[학술지(정기간행물)] - Yuan SM / 2015 / Potential cardioprotective effects of Ginseng preparations / Pak J Pharm Sci 28 : 963 ~ 968
[학술지(정기간행물)] - Park J / 1996 / Recent studies on the chemical constituents of Korean ginseng (Panax ginseng CA Meyer) / Korean J Ginseng Sci 20 : 389 ~ 415
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