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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.22 No.4
- 발행연도
- 2017.12
- 수록면
- 320 - 326 (7page)
- DOI
- 10.3746/pnf.2017.22.4.320
이용수
이 논문의 연구 히스토리 (10)
2017
Kaempferol Inhibits Angiogenesis by Suppressing HIF-1α and VEGFR2 Activation via ERK/p38 MAPK and PI3K/Akt/mTOR Signaling Pathways in Endothelial Cells
Gi Dae Kim
Preventive Nutrition and Food Science
2017.12
학술저널
Effects of Korean Red Ginseng Extract on Endothelial Proliferation and Angiogenesis through Activating the MAPK and PI3K/AKT/mTOR Signaling Pathway
Gi Dae Kim
,
Jedo Oh
,
Sang Kook Lee
한국식품영양과학회 학술대회발표집
2017.10
학술대회자료
Antofine, a Natural Phenanthroindolizidine Alkaloid, Suppresses Angiogenesis via Regulation of AKT/mTOR and AMPK Pathway in Endothelial Cells and Endothelial Progenitor Cells Derived from Mouse Embryonic Stem Cells
Gi Dae Kim
,
Jedo Oh
,
Sang Kook Lee
한국식품영양과학회 학술대회발표집
2017.10
학술대회자료
2016
Honokiol Inhibits Vascular Vessel Formation of Mouse Embryonic Stem Cell-derived Endothelial Cells via the Suppression of PECAM and MAPK/mTOR Signaling Pathway
Gi Dae Kim
,
Jedo Oh
,
Sang Kook Lee
한국식품영양과학회 학술대회발표집
2016.10
학술대회자료
Hesperidin inhibits vascular formation by blocking the AKT/mTOR signaling pathways
Gi Dae Kim
,
Jedo Oh
,
Sang Kook Lee
한국식품영양과학회 학술대회발표집
2016.10
학술대회자료
2014
Hesperetin Inhibits Vascular Formation by Suppressing of the PI3K/AKT, ERK, and p38 MAPK Signaling Pathways.
Gi Dae Kim
Preventive Nutrition and Food Science
2014.12
학술저널
Magnolol Inhibits Angiogenesis by Regulating ROS-mediated Apoptosis and the PI3K/AKT/mTOR Signaling Pathway in mES/EB-derived Endothelial-like Cells
Gi Dae Kim
,
Jedo Oh
,
Sang Kook Lee
한국식품영양과학회 학술대회발표집
2014.10
학술대회자료
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초록· 키워드
오류제보하기
Kaempferol has been shown to inhibit vascular formation in endothelial cells. However, the underlying mechanisms are not fully understood. In the present study, we evaluated whether kaempferol exerts antiangiogenic effects by targeting extracellular signal-regulated kinase (ERK)/p38 mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) signaling pathways in endothelial cells. Endothelial cells were treated with various concentrations of kaempferol for 24 h. Cell viability was determined by the 3- (4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide assay; vascular formation was analyzed by tube formation, wound healing, and mouse aortic ring assays. Activation of hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor receptor 2 (VEGFR2), ERK/p38 MAPK, and PI3K/Akt/mTOR was analyzed by Western blotting. Kaempferol significantly inhibited cell migration and tube formation in endothelial cells, and suppressed microvessel sprouting in the mouse aortic ring assay. Moreover, kaempferol suppressed the activation of HIF-1α, VEGFR2, and other markers of ERK/p38 MAPK and PI3K/Akt/mTOR signaling pathways in endothelial cells. These results suggest that kaempferol inhibits angiogenesis by suppressing HIF-1α and VEGFR2 activation via ERK/p38 MAPK and PI3K/Akt/mTOR signaling in endothelial cells.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
Kerbel RS. 2008. Tumor angiogenesis. N Engl J Med 358: 2039- 2049.
Cristi E, Perrone G, Toscano G, Verzi A, Nori S, Santini D, Tonini G, Vetrani A, Fabiano A, Rabitti C. 2005. Tumour proliferation, angiogenesis, and ploidy status in human colon cancer. J Clin Pathol 58: 1170-1174.
Kanno S, Oda N, Abe M, Terai Y, Ito M, Shitara K, Tabayashi K, Shibuya M, Sato Y. 2000. Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells. Oncogene 19: 2138-2146.
Meadows KN, Bryant P, Vincent PA, Pumiglia KM. 2004. Activated Ras induces a proangiogenic phenotype in primary endothelial cells. Oncogene 23: 192-200.
Wu G, Luo J, Rana JS, Laham R, Sellke FW, Li J. 2006. Involvement of COX-2 in VEGF-induced angiogenesis via P38 and JNK pathways in vascular endothelial cells. Cardiovasc Res 69: 512-519.
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
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Kaempferol Inhibits Angiogenesis through the Suppression of HIF-1α and VEGFR2 Expression via ERK/p38 MAPK-Dependent and PI3K/AKT/mTOR Signaling Pathways in Endothelial Cells.
한국식품영양과학회 학술대회발표집
2017 .10
-
Effects of Korean Red Ginseng Extract on Endothelial Proliferation and Angiogenesis through Activating the MAPK and PI3K/AKT/mTOR Signaling Pathway
한국식품영양과학회 학술대회발표집
2017 .10
-
Myricetin Inhibits Angiogenesis by Regulating ROS-Mediated Apoptosis and the PI3K/AKT/mTOR Signaling Pathway in Endothelial Cells.
한국식품영양과학회 학술대회발표집
2017 .10
-
Hesperidin Inhibits Vascular Formation by Blocking the AKT/mTOR Signaling Pathways
Preventive Nutrition and Food Science
2015 .12
-
Honokiol Inhibits Vascular Vessel Formation of Mouse Embryonic Stem Cell-derived Endothelial Cells via the Suppression of PECAM and MAPK/mTOR Signaling Pathway
한국식품영양과학회 학술대회발표집
2016 .10
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Carnosine inhibits angiogenesis by inhibiting VEGFR-2-mediated ERK/AKT/eNOS signaling pathway
한국식품영양과학회 학술대회발표집
2019 .10
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Antofine, a Natural Phenanthroindolizidine Alkaloid, Suppresses Angiogenesis via Regulation of AKT/mTOR and AMPK Pathway in Endothelial Cells and Endothelial Progenitor Cells Derived from Mouse Embryonic Stem Cells
한국식품영양과학회 학술대회발표집
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Hesperidin inhibits vascular formation by blocking the AKT/mTOR signaling pathways
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Kaempferol promotes bacterial pathogen resistance through the activation of NPR1 by both SA and MPK signaling pathways in Arabidopsis
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Inhibitory Effect of Phenolic Compounds on Vascular Endothelial Growth Factor-Induced Retinal Endothelial Permeability and Angiogenesis
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Gelidium elegans Extract Ameliorates Type 2 Diabetes Mellitus through Negative Regulation of MAPK Signaling Pathway by PI3K/Akt Activation
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UCI(KEPA) : I410-ECN-0101-2018-594-001729195