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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.28 No.4
- 발행연도
- 2023.12
- 수록면
- 436 - 443 (8page)
이용수
이 논문의 연구 히스토리 (10)
2017
Kaempferol Inhibits Angiogenesis by Suppressing HIF-1α and VEGFR2 Activation via ERK/p38 MAPK and PI3K/Akt/mTOR Signaling Pathways in Endothelial Cells
Gi Dae Kim
Preventive Nutrition and Food Science
2017.12
학술저널
Effects of Korean Red Ginseng Extract on Endothelial Proliferation and Angiogenesis through Activating the MAPK and PI3K/AKT/mTOR Signaling Pathway
Gi Dae Kim
,
Jedo Oh
,
Sang Kook Lee
한국식품영양과학회 학술대회발표집
2017.10
학술대회자료
Antofine, a Natural Phenanthroindolizidine Alkaloid, Suppresses Angiogenesis via Regulation of AKT/mTOR and AMPK Pathway in Endothelial Cells and Endothelial Progenitor Cells Derived from Mouse Embryonic Stem Cells
Gi Dae Kim
,
Jedo Oh
,
Sang Kook Lee
한국식품영양과학회 학술대회발표집
2017.10
학술대회자료
2016
Honokiol Inhibits Vascular Vessel Formation of Mouse Embryonic Stem Cell-derived Endothelial Cells via the Suppression of PECAM and MAPK/mTOR Signaling Pathway
Gi Dae Kim
,
Jedo Oh
,
Sang Kook Lee
한국식품영양과학회 학술대회발표집
2016.10
학술대회자료
Hesperidin inhibits vascular formation by blocking the AKT/mTOR signaling pathways
Gi Dae Kim
,
Jedo Oh
,
Sang Kook Lee
한국식품영양과학회 학술대회발표집
2016.10
학술대회자료
2014
Hesperetin Inhibits Vascular Formation by Suppressing of the PI3K/AKT, ERK, and p38 MAPK Signaling Pathways.
Gi Dae Kim
Preventive Nutrition and Food Science
2014.12
학술저널
Magnolol Inhibits Angiogenesis by Regulating ROS-mediated Apoptosis and the PI3K/AKT/mTOR Signaling Pathway in mES/EB-derived Endothelial-like Cells
Gi Dae Kim
,
Jedo Oh
,
Sang Kook Lee
한국식품영양과학회 학술대회발표집
2014.10
학술대회자료
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초록· 키워드
오류제보하기
Liver cancer is a globally common form of cancer. Thus, novel drugs derived from natural products are needed to reduce the side effects of chemotherapy. The present study aimed to analyze the anticancer properties and effects of harmine hydrochloride (HMH), a water-soluble metabolite of harmine that can be easily absorbed into tissues, in treating liver cancer cells. HMH dose-dependently inhibited cell growth, migration, invasion, and colony formation in SK-Hep1 cells. It also induced G2/M arrest by reducing the expression of p-cdc2, cyclin B1, and Rb (G2/M phase regulatory proteins) in a dose-dependent manner. HMH treatment reduced the expression of caspase-9, caspase-3, PARP, and Bcl-2 and increased the expression of Bax (a proapoptotic protein). Moreover, it increased the production of reactive oxygen species and decreased the intracellular uptake of rhodamine 123 due to mitochondrial dysfunction because of oxidative stress. HMH treatment also upregulated the phosphorylation of JNK, p38, and FOXO3a in SK-Hep1 cells and downregulated the PI3K/AKT signaling pathway. Our findings suggest that HMH may activate the compounds responsible for anticancer effects in hepatocellular carcinoma cells.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
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Harmine hydrochloride triggers G2/M cell cycle arrest and apoptosis in HCT116 cells through ERK and PI3K/ AKT/mTOR signaling pathways
한국식품영양과학회 학술대회발표집
2021 .10
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Harmine hydrochloride mediates the induction of G2/M cell cycle arrest in breast cancer cells by regulating the MAPKs and AKT/FOXO3a signaling pathways
한국식품영양과학회 학술대회발표집
2022 .10
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Harmine hydrochloride triggers G2/M cell cycle arrest and apoptosis in HCT116 colon cancer cells through PI3K/AKT signalling pathways
한국식품영양과학회 학술대회발표집
2020 .10
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Harmine Hydrochloride induces G2/M arrest in MDA-MB-231 and MCF-7 human breast cancer cells by regulating the PI3K/AKT/mTOR signaling pathway
한국식품영양과학회 학술대회발표집
2020 .10
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Harmine hydrochloride induces G2/M phase cell cycle arrest by activation of JNK and p53/p21 upregulation in HCT116 colon cancer cells
한국식품영양과학회 학술대회발표집
2019 .10
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Dendropanax Morbifera induced G0/G1 arrest and apoptosis in SK-Hep1 human hepatoma cancer cells by modulating the PI3K/AKT/mTOR signaling pathways
한국식품영양과학회 학술대회발표집
2020 .10
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Ursolic acid Decreases the Proliferation of MCF-7 Cell-derived Breast Cancer Stem-like Cells by Modulating the ERK and PI3K/AKT Signaling Pathways
한국식품영양과학회 학술대회발표집
2021 .10
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Dioscin reduces cell proliferation through cell cycle arrest by modulating AKT/p53/p21 signaling pathways in breast cancer stem-like cells
한국식품영양과학회 학술대회발표집
2019 .10
-
Ursolic acid induces G0/G1 cell cycle arrest by regulating AKT/p53/p21 and MAPK signaling pathways in breast cancer stem-like cells
한국식품영양과학회 학술대회발표집
2019 .10
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Krill oil inhibits the proliferation and migration of bladder cancer via regulating G1-phase cell cycle arrest, PI3K/AKT and MAPK signaling, and MMP-9 expression
한국식품영양과학회 학술대회발표집
2022 .10
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Yuja Hot Water Extract Prevents Dexamethasone-Induced Protein Degradation in Skeletal Muscle of C2C12 Cells and Mice by Regulating the PI3K-Akt-FoxO3α Signaling Pathway
한국식품영양과학회 학술대회발표집
2024 .10
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인체위암 세포에서 PI3K/AKT 신호 전달계 차단에 의한 동충하초 유래 Cordycepin의 Apoptosis 유발 효과 증진
한국식품영양과학회지
2016 .06
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Pyrogallol Induces G0/G1 Cell Cycle Arrest and Apoptosis through Mitochondrial Pathway in PC-3 Human Prostate Cancer Cells
한국식품영양과학회 학술대회발표집
2018 .10
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Dioscin decreases breast cancer stem cell proliferation via cell cycle arrest by modulating p38 MAPK and AKT/mTOR signaling pathways
한국식품영양과학회 학술대회발표집
2022 .10
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Neuroprotective Effects of Sargahydroquinoic Acid against Aβ25-35-Induced Oxidative Stress: Targeting PI3K/AKT/Nrf2 Signaling Pathway
한국식품영양과학회 학술대회발표집
2021 .10
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Extracts from Cnidium monnieri (L.) Cusson induces Apoptosis and Cell Cycle Arrest through Regulating Akt/GSK-3β Signaling Pathways and Cyclooxygenase-2 expression in HT-29 Colon Cancer Cells
한국식품영양과학회 학술대회발표집
2016 .10
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Anti-cancer Effects of Filbertone in Hepatocellular Carcinoma Cells
한국식품영양과학회 학술대회발표집
2023 .10
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Kaempferol, Quercetin 및 그 배당체의 Hydrogen Peroxide에 의한 신경세포의 산화적 스트레스 보호 효과
농업생명환경연구
2024 .09
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천마 추출물을 처리한 간암 세포에서 Bcl-2, Bax 및 AMPKα 발현과 세포 자멸사에 미치는 영향 분석
한국약용작물학회지
2022 .10
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An Odorant Induces Cell Cycle Arrest via ERK Pathway in Human Colon Cancer Cells
한국식품영양과학회 학술대회발표집
2020 .10
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