지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.2
- 수록면
- 100 - 112 (13page)
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초록· 키워드
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The complement is a part of the immune system that plays several roles in removing pathogens. Despite the importance of the complement system, the exact role of each component has been overlooked because the complement system was thought to be a nonspecific humoral immune mechanism that worked against pathogens. Decay-accelerating factor (DAF or CD55) is a known inhibitor of the complement system and has recently attracted substantial attention due to its role in various diseases, such as cancer, proteinlosing enteropathy, and malaria. Some protein-losing enteropathy cases are caused by CD55 deficiency, which leads to complement hyperactivation, malabsorption, and angiopathic thrombosis. In addition, CD55 has been reported to be an essential host receptor for infection by the malaria parasite. Moreover, CD55 is a ligand of the seven-span transmembrane receptor CD97. Since CD55 is present in various cells, the functional role of CD55 has been expanded by showing that CD55 is associated with a variety of diseases, including cancer, malaria, proteinlosing enteropathy, paroxysmal nocturnal hemoglobinuria, and autoimmune diseases. This review summarizes the current understanding of CD55 and the role of CD55 in these diseases. It also provides insight into the development of novel drugs for the diagnosis and treatment of diseases associated with CD55.
목차
ABSTRACT
INTRODUCTION
CD55
CD55 AND ITS RECEPTOR CD97
CONCLUSION AND PERSPECTIVE
REFERENCES
참고문헌 (90)
참고문헌 신청
Morgan RA / 2010 / Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2 / Mol Ther 18:843~851
Couzin-Frankel J / 2013 / Breakthrough of the year 2013. Cancer immunotherapy / Science 342:1432~1433
Macor P / 2007 / Complement as effector system in cancer immunotherapy / Immunol Lett 111:6~13
Pio R / 2013 / Complement inhibition in cancer therapy / Semin Immunol 25:54~64
Lukacik P / 2004 / Complement regulation at the molecular level: the structure of decay-accelerating factor / Proc Natl Acad Sci U S A 101:1279~1284
Couzin-Frankel J / 2013 / Breakthrough of the year 2013. Cancer immunotherapy / Science 342:1432~1433
Macor P / 2007 / Complement as effector system in cancer immunotherapy / Immunol Lett 111:6~13
Pio R / 2013 / Complement inhibition in cancer therapy / Semin Immunol 25:54~64
Lukacik P / 2004 / Complement regulation at the molecular level: the structure of decay-accelerating factor / Proc Natl Acad Sci U S A 101:1279~1284
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UCI(KEPA) : I410-ECN-0101-2018-517-001801180