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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 138 - 144 (7page)
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Background Targeted therapy has revolutionized the management of Philadelphia chromo-some-positive (Ph+) acute lymphoblastic leukemia (ALL); however, relapse still occurs because of the presence of quiescent stem cells, termed leukemia propagating cells (LPCs). This study aimed to assess the phenotypic diversity of LPCs in adult patients with Ph+ B-Acute ALL (B-ALL) and to assess its prognostic impact. Methods Seventy adults with newly diagnosed Ph+ B-ALL were recruited at the Mansoura Oncology Center. Multiparameter flow cytometry studies of mononuclear blast cells for cluster of differentiation (CD)34, CD38, and CD58 were performed. Results Seventeen patients had blasts with the pattern of LPCs (CD34+CD38-CD58-), while 53 cases had other diverse phenotypic patterns. The rate of complete response was significantly lower in patients with the LPC phenotype (47% vs. 81%, P=0.006). The median time to achieve a complete response was prolonged in patients with the CD34+ CD38-CD58- phenotype (48 vs. 32 days, P=0.016). The three-year overall survival was significantly lower in patients with the CD34+CD38-CD58- phenotype (37% vs. 55% respectively, P=0.028). Multivariate analysis showed that the CD34+CD38- CD58- phenotype was an independent risk factor for overall survival. Conclusion The presence of CD34+CD38-CD58- LPCs at diagnosis allows rapid identification of higher risk patients. Risk stratification of these patients is needed to further guide therapy and develop effective LPCs-targeted therapy to improve treatment outcome.
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참고문헌 (19)
참고문헌 신청
Ottmann OG / 2009 / Management of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) / Hematology Am Soc Hematol Educ Program :371~381
Bassan R / 2011 / Modern therapy of acute lymphoblastic leukemia / J Clin Oncol 29:532~543
Gokbuget N / 2009 / Treatment of adult acute lymphoblastic leukemia / Semin Hematol 46:64~75
Cobaleda C / 2000 / A primitive hematopoietic cell is the target for the leukemic transformation in human Philadelphia-positive acute lymphoblastic leukemia / Blood 95:1007~1013
Lapidot T / 1994 / A cell initiating human acute myeloid leukaemia after transplantation into SCID mice / Nature 367:645~648
Bassan R / 2011 / Modern therapy of acute lymphoblastic leukemia / J Clin Oncol 29:532~543
Gokbuget N / 2009 / Treatment of adult acute lymphoblastic leukemia / Semin Hematol 46:64~75
Cobaleda C / 2000 / A primitive hematopoietic cell is the target for the leukemic transformation in human Philadelphia-positive acute lymphoblastic leukemia / Blood 95:1007~1013
Lapidot T / 1994 / A cell initiating human acute myeloid leukaemia after transplantation into SCID mice / Nature 367:645~648
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