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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.23 No.1
- 발행연도
- 2018.3
- 수록면
- 15 - 21 (7page)
- DOI
- 10.3746/pnf.2018.23.1.15
이용수
초록· 키워드
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S-Allyl cysteine (SAC) is found in garlic and has been reported to exert antidiabetic and antiobesity properties in drug-induced adult experimental models of metabolic dysfunction, but its potential beneficial effects in high-fructose diet neonatal rat models have not been determined. This study investigated the potential prophylactic effects of SAC in high-fructose diet fed suckling rat pups modelling human neonates fed a high-fructose diet. Four-day-old male (n=32) and female (n=32) Wistar rat pups, were randomly assigned to and administered the following treatment regimens daily for 15 days: group I, distilled water; group II, 20% fructose solution (FS); group III, SAC; group IV, SAC+FS. The pups’ blood glucose, triglyceride, cholesterol, plasma leptin and insulin concentration, liver lipid content, and liver histology were determined at termination. In female rat pups, orally administered SAC prevented FS-induced hypoinsulinemia but significantly increased (P≤0.05) liver lipid content. Oral administration of SAC significantly increased (P≤0.05) plasma insulin concentration and homeostasis model assessment for insulin resistance in the male pups. The potential sexually dimorphic effects of SAC (insulinotropic effects in male pups and protection of female pups against fructose-induced hypoinsulinemia) suggest that SAC could be potentially exploited as an antidiabetic and insulinotropic agent. Caution should, however, be exercised in the use of SAC during suckling as it could result in excessive liver lipid accumulation and insulin resistance.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (33)
참고문헌 신청
World Health Organisation (WHO) / 2014 / Global target 7: Halt the rise in diabetes and obesity. In Global Status Report on Noncommunicable Diseases 2014, Vol 174 :79~94
Ching RHH / 2011 / Supplementation of bitter melon to rats fed a high-fructose diet during gestation and lactation ameliorates fructose-induced dyslipidemia and hepatic oxidative stress in male offspring / J Nutr 141:1664~1672
Mager DR / 2015 / The effect of a low fructose and low glycemic index/load (FRAGILE) dietary intervention on indices of liver function, cardiometabolic risk factors, and body composition in children and adolescents with nonalcoholic fatty liver disease (NAFLD) / J Parenter Enteral Nutr 39:73~84
Yamada L / 2017 / Epigenetic studies in Developmental Origins of Health and Disease: pitfalls and key considerations for study design and interpretation / J Dev Origins Health Dis 8:30~43
Kappil M / 2016 / Developmental origins of common disease: epigenetic contributions to obesity / Annu Rev Genomics Hum Genet 17:177~192
Ching RHH / 2011 / Supplementation of bitter melon to rats fed a high-fructose diet during gestation and lactation ameliorates fructose-induced dyslipidemia and hepatic oxidative stress in male offspring / J Nutr 141:1664~1672
Mager DR / 2015 / The effect of a low fructose and low glycemic index/load (FRAGILE) dietary intervention on indices of liver function, cardiometabolic risk factors, and body composition in children and adolescents with nonalcoholic fatty liver disease (NAFLD) / J Parenter Enteral Nutr 39:73~84
Yamada L / 2017 / Epigenetic studies in Developmental Origins of Health and Disease: pitfalls and key considerations for study design and interpretation / J Dev Origins Health Dis 8:30~43
Kappil M / 2016 / Developmental origins of common disease: epigenetic contributions to obesity / Annu Rev Genomics Hum Genet 17:177~192
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UCI(KEPA) : I410-ECN-0101-2018-594-001907108