지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.4
- 수록면
- 183 - 191 (9page)
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초록· 키워드
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Background: Ginseng saponin has long been used as a traditional Asian medicine and is known to be effective in treating various kinds of pain. Ginsenoside Rf is one of the biologically active saponins found in ginseng. We evaluated ginsenoside Rf’s antinociceptive and anti-inflammatory effects, and its mechanism of action on adrenergic and serotonergic receptors, in an incisional pain model.
Methods: Mechanical hyperalgesia was induced via plantar incision in rats followed by intraperitoneal administration of increasing doses of ginsenoside Rf (vehicle, 0.5 mg/kg, 1 mg/kg, 1.5 mg/kg, and 2 mg/kg). The antinociceptive effect was also compared in a Positive Control Group that received a ketorolac (30 mg/kg) injection, and the Naïve Group, which did not undergo incision. To evaluate the mechanism of action, rats were treated with prazosin (1 mg/kg), yohimbine (2 mg/kg), or ketanserin (1 mg/kg) prior to receiving ginsenoside Rf (1.5 mg/kg). The mechanical withdrawal threshold was measured using von Frey filaments at various time points before and after ginsenoside Rf administration. To evaluate the antiinflammatory effect, serum interleukin (IL)-1β, IL-6, and tumor necrotizing factor-α levels were measured.
Results: Ginsenoside Rf increased the mechanical withdrawal threshold significantly, with a curvilinear doseeresponse curve peaking at 1.5 mg/kg. IL-1β, IL-6, and tumor necrotizing factor-a levels significantly decreased after ginsenoside Rf treatment. Ginsenoside Rf’s antinociceptive effect was reduced by yohimbine, but potentiated by prazosin and ketanserin.
Conclusion: Intraperitoneal ginsenoside Rf has an antinociceptive effect peaking at a dose of 1.5 mg/kg. Anti-inflammatory effects were also detected.
Methods: Mechanical hyperalgesia was induced via plantar incision in rats followed by intraperitoneal administration of increasing doses of ginsenoside Rf (vehicle, 0.5 mg/kg, 1 mg/kg, 1.5 mg/kg, and 2 mg/kg). The antinociceptive effect was also compared in a Positive Control Group that received a ketorolac (30 mg/kg) injection, and the Naïve Group, which did not undergo incision. To evaluate the mechanism of action, rats were treated with prazosin (1 mg/kg), yohimbine (2 mg/kg), or ketanserin (1 mg/kg) prior to receiving ginsenoside Rf (1.5 mg/kg). The mechanical withdrawal threshold was measured using von Frey filaments at various time points before and after ginsenoside Rf administration. To evaluate the antiinflammatory effect, serum interleukin (IL)-1β, IL-6, and tumor necrotizing factor-α levels were measured.
Results: Ginsenoside Rf increased the mechanical withdrawal threshold significantly, with a curvilinear doseeresponse curve peaking at 1.5 mg/kg. IL-1β, IL-6, and tumor necrotizing factor-a levels significantly decreased after ginsenoside Rf treatment. Ginsenoside Rf’s antinociceptive effect was reduced by yohimbine, but potentiated by prazosin and ketanserin.
Conclusion: Intraperitoneal ginsenoside Rf has an antinociceptive effect peaking at a dose of 1.5 mg/kg. Anti-inflammatory effects were also detected.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (48)
참고문헌 신청
[학술지(정기간행물)] - Liu CX / 1992 / Recent advances on ginseng research in China / J Ethnopharmacol 36 : 27 ~ 38
[학술지(정기간행물)] - Kaku T / 1975 / Chemico-pharmacological studies on saponins of Panax ginseng C. A. Meyer. II. Pharmacological part / Arzneimittelforschung 25 : 539 ~ 547
[학술지(정기간행물)] - Kim WJ / 2014 / Antihyperalgesic effects of ginseng total saponins in a rat model of incisional pain / J Surg Res 187 : 169 ~ 175
[학술지(정기간행물)] - Mogil JS / 1998 / Ginsenoside Rf, a trace component of ginseng root, produces antinociception in mice / Brain Res 792 : 218 ~ 228
[학술지(정기간행물)] - Nemmani KV / 2003 / Ginsenoside Rf potentiates U-50,488H-induced analgesia and inhibits tolerance to its analgesia in mice / Life Sci 72 : 759 ~ 768
[학술지(정기간행물)] - Kaku T / 1975 / Chemico-pharmacological studies on saponins of Panax ginseng C. A. Meyer. II. Pharmacological part / Arzneimittelforschung 25 : 539 ~ 547
[학술지(정기간행물)] - Kim WJ / 2014 / Antihyperalgesic effects of ginseng total saponins in a rat model of incisional pain / J Surg Res 187 : 169 ~ 175
[학술지(정기간행물)] - Mogil JS / 1998 / Ginsenoside Rf, a trace component of ginseng root, produces antinociception in mice / Brain Res 792 : 218 ~ 228
[학술지(정기간행물)] - Nemmani KV / 2003 / Ginsenoside Rf potentiates U-50,488H-induced analgesia and inhibits tolerance to its analgesia in mice / Life Sci 72 : 759 ~ 768
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