지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 524 - 528 (5page)
이용수
초록· 키워드
오류제보하기
Ricinus communis, belongs to the family Euphorbiaceae, has been known as medicinal plants for treatment of inflammation, tumors, antidiabetic, hepatoprotective and laxative. Compared to many pharmacological studies, the effect of R. communis extract on regulating adipogenesis as therapeutic drug for treating obesity has not been reported. R. communis extract (RCE) was investigated to determine its effects on the adipogenesis by monitoring the status of Wnt/β-catenin signaling and factors involving the differentiation of adipocytes. The differentiation of 3T3-L1 cells monitored by Oil Red O staining was inhibited in concentration dependent manner by RCE. The luciferase activity of HEK 293-TOP cells containing pTOPFlash with Tcf4 response element-luciferase gene was increased approximately 2-folds by the treatment of RCE at concentrations of 100 μg/mL compared to the control. Activation of the Wnt/β-catenin pathway by RCE was further confirmed by immunocytochemical analysis which shows an increment of nuclear localization of β-catenin. In addition, safety of RCE was verified through performing neural stem cell morphology assay. Among the identified flavonoids in RCE, isoquercitrin was the most abundant. Therefore, these results indicate that the adipocyte differentiation was significantly reduced by isoquercitrin in R. communis. In this study, RCE suppresses the adipogenesis of 3T3-L1 cells via the activation of Wnt/β-catenin signaling.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
References
참고문헌 (19)
참고문헌 신청
[학술지(정기간행물)] - Liu J / 2004 / Regulating the balance between peroxisome proliferator-activated receptor γ and β-catenin signaling during adipogenesis. A glycogen synthase kinase 3β phosphorylation-defective mutant of β-catenin inhibits expression of a subset of adipogenic genes / J Biol Chem 279 : 45020 ~ 45027
[학술지(정기간행물)] - Logan CY / 2004 / The Wnt signaling pathway in development and disease / Annu Rev Cell Dev Biol 20 : 781 ~ 810
[학술지(정기간행물)] - Ross SE / 2000 / Inhibition of adipogenesis by Wnt signaling / Science 289 : 950 ~ 953
[학술지(정기간행물)] - Kennell JA / 2005 / Wnt signaling inhibits adipogenesis through β-catenin-dependent and-independent mechanisms / J Biol Chem 280 : 24004 ~ 24010
[학술지(정기간행물)] - Fruhbeck G / 2001 / The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation / Am J Physiol Endocrinol Metab 280 : 827 ~ 847
[학술지(정기간행물)] - Logan CY / 2004 / The Wnt signaling pathway in development and disease / Annu Rev Cell Dev Biol 20 : 781 ~ 810
[학술지(정기간행물)] - Ross SE / 2000 / Inhibition of adipogenesis by Wnt signaling / Science 289 : 950 ~ 953
[학술지(정기간행물)] - Kennell JA / 2005 / Wnt signaling inhibits adipogenesis through β-catenin-dependent and-independent mechanisms / J Biol Chem 280 : 24004 ~ 24010
[학술지(정기간행물)] - Fruhbeck G / 2001 / The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation / Am J Physiol Endocrinol Metab 280 : 827 ~ 847
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UCI(KEPA) : I410-ECN-0101-2018-059-001945337