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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.5
- 수록면
- 33 - 42 (10page)
이용수
초록· 키워드
오류제보하기
Pim kinases are important targets for hematological cancer therapy because they are involved in key cellular processes such as differentiation, proliferation, survival, apoptosis, and tumorigenesis. Here, inhibitors of Pim kinases were designed and synthesized based on an indolin-2-one scaffold. Introduction of a (1H-imidazol-5-yl)methylenyl group at position 3, a 3-aminopiperidinyl group at position 4, and an amino group at position 5 of indolin-2-one resulted in inhibited Pim kinase activity. Compounds 7a and 7d showed submicromolar IC<SUB>50</SUB> values against all three Pim kinases.
목차
Abstract
Introduction
Experimental
Results and Discussion
Conclusion
References
참고문헌 (13)
참고문헌 신청
[학술지(정기간행물)] - 정규원 / 2017 / Prediction of Cancer Incidence and Mortality in Korea, 2017 / Cancer Research and Treatment 49 (2) : 306 ~ 312
[학술지(정기간행물)] - De Kouchkovsky I / 2016 / Acute myeloid leukemia: a comprehensive review and 2016 update / Blood Cancer Journal 6 : e441 ~
[학술지(정기간행물)] - Pigneux A / 2017 / Addition of androgens improves survival in dlderly patients with acute myeloid leukemia: A GOELAMS study / J Clin Oncol 35 : 387 ~ 393
[학술지(정기간행물)] - Zhou J / 2009 / Enhanced activation of STAT pathways and overexpression of survivin confer resistance to FLT3 inhibitors and could be therapeutic targets in AML / Blood 113 : 4052 ~ 4062
[학술지(정기간행물)] - Blanco-Aparicio C / 2013 / Pim kinases in cancer: Diagnostic, prognostic and treatment opportunities / Biochem Pharmacol 85 : 629 ~ 643
[학술지(정기간행물)] - De Kouchkovsky I / 2016 / Acute myeloid leukemia: a comprehensive review and 2016 update / Blood Cancer Journal 6 : e441 ~
[학술지(정기간행물)] - Pigneux A / 2017 / Addition of androgens improves survival in dlderly patients with acute myeloid leukemia: A GOELAMS study / J Clin Oncol 35 : 387 ~ 393
[학술지(정기간행물)] - Zhou J / 2009 / Enhanced activation of STAT pathways and overexpression of survivin confer resistance to FLT3 inhibitors and could be therapeutic targets in AML / Blood 113 : 4052 ~ 4062
[학술지(정기간행물)] - Blanco-Aparicio C / 2013 / Pim kinases in cancer: Diagnostic, prognostic and treatment opportunities / Biochem Pharmacol 85 : 629 ~ 643
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UCI(KEPA) : I410-ECN-0101-2018-047-002155004