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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.5
- 수록면
- 47 - 60 (14page)
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초록· 키워드
오류제보하기
PIM kinases that consist of three isoforms, PIM-1, PIM-2, and PIM-3 play a critical role in regulating cell cycle, survival, proliferation, and the homing and migration. PIM kinases have been found to be upregulated in various human hematological and solid tumors. Therefore, the PIM kinases represent potential drug targets for anticancer therapy. To achieve highly potent and selective PIM kinase inhibitors, unique structural features in the ATP-binding pocket of PIM kinases were targeted. We performed a structure-based drug design using the AutoDock vina program and the X-ray crystal structures of human PIM kinases and identified a series of 1,3,4-oxadiazole-2(3H)-thione analogs as promising PIM kinase inhibitors.
목차
ABSTRACT
Introduction
Experimental
Results and Discussion
Conclusion
References
참고문헌 (16)
참고문헌 신청
Xinning Zhang / 2018 / PIM Kinase as an Executional Target in Cancer / 대한암예방학회지 23(3):109~116
Warfel NA / 2015 / PIM kinase(and Akt)biology and signaling in tumors / Pharmacol Ther 151:41~49
Garcia PD / 2014 / Pan-PIM kinase inhibition provides a novel therapy for treating hematologic cancers / Clin Cancer Res 20:1834~1845
Narlik-Grassow M / 2014 / The PIM family of serine/threonine kinases in cancer / Med Res Rev 34:136~159
Amaravadi R / 2005 / The survival kinases Akt and Pim as potential pharmacological targets / J Clin Invest 115:2618~2624
Warfel NA / 2015 / PIM kinase(and Akt)biology and signaling in tumors / Pharmacol Ther 151:41~49
Garcia PD / 2014 / Pan-PIM kinase inhibition provides a novel therapy for treating hematologic cancers / Clin Cancer Res 20:1834~1845
Narlik-Grassow M / 2014 / The PIM family of serine/threonine kinases in cancer / Med Res Rev 34:136~159
Amaravadi R / 2005 / The survival kinases Akt and Pim as potential pharmacological targets / J Clin Invest 115:2618~2624
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