PIM Kinase as an Executional Target in Cancer

Xinning Zhang; Mengqiu Song; Joydeb Kumar Kundu; 이미현; Zhen-Zhen Liu

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자료유형: 학술저널

저자정보: Xinning Zhang (Affiliated Cancer Hospital of Zhengzhou University) Mengqiu Song (Zhengzhou University) Joydeb Kumar Kundu (University of Alberta) 이미현 (Zhengzhou University) Zhen-Zhen Liu (Affiliated Cancer Hospital of Zhengzhou University)

저널정보: 대한암예방학회 대한암예방학회지 대한암예방학회지 제23권 제3호

발행연도: 2018.1

수록면: 109 - 116 (8page)

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PIM (proviral integration site for moloney murine leukemia virus) kinase plays a key role as an oncogene in various cancers includingmyeloma, leukemia, prostate and breast cancers. The aberrant expression and/or activation of PIM kinases in various cancers follow anisoform-specific pattern. While PIM1 is predominantly expressed in hematological and solid tumors, PIM2 and PIM3 are largely expressedin leukemia and solid tumors, respectively. All of PIM kinases cause transcriptional activation of genes involved in cell survival and cellcycle progression in cancer. A variety of pro-tumorigenic signaling molecules, such as MYC, p21Cip1/Waf1/p27kip1, CDC25, Notch1 and BADhave been identified as the downstream targets of PIM kinases. So far, three kinds of adenosine triphosphate-competitive PIM inhibitors,SGI-1776, AZD1208, and LGH447 have been in clinical trials for the treatment of acute myelogenous leukemia, prostate cancer, lymphoma,or multiple myeloma. This review sheds light on the signaling pathways involved in the PIM kinase regulation and current status ofdeveloping PIM kinase inhibitors as clinical success in combating human cancer.

참고문헌 (3)

참고문헌 신청

장수화 / 2012 / MYC and PIM2 Co-Expression in Mouse Bone Marrow Cells Readily Establishes Permanent Myeloid Cell Lines That Can Induce Lethal Myeloid Sarcoma In Vivo / Molecules and Cells 34(2):201~208

Yang Q / 2013 / Combination of Pim kinase inhibitor SGI-1776 and bendamustine in B-cell lymphoma / Clin Lymphoma Myeloma Leuk 13(Suppl 2):S355~S362

김대식 / 2008 / Association of Single Nucleotide Polymorphisms in PIM-1 Gene with the Risk of Korean Lung Cancer / Cancer Research and Treatment 40(4):190~196

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