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[학술저널]

  • 학술저널

이환 차선숙 이명렬 장해춘 이재준

UCI(KEPA) : I410-ECN-0101-2018-059-003066840

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The present study was carried out to investigate the in vivo single-dose toxicity of Leuconostoc citreum GR1 , a ;actic acid bacteria isolated from kimchi, in ICR male and female mice. The test article was orallly adminisyered once to both sexes of mice. The mortalities, clinical findings, autopsy findings, and body weight changes were monitored daily for two weeks. The male and female mice were gavaged with Leuc. kimchi GRI of four doses. The oral LDso of Leuc. citreum GRI was considered higher than 5,000 mg/kg. Nosignificant changes in the general conditions, body weights, clinical signs and presence of gross lesions were boserved in both sexes of mice to whom Leuc. cireum GRI was administered orally. The results indicated that the 5,000 mg/kg dose of Leuc. citreum GRI showed no adverse effect.

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