Meta-analysis of randomized controlled trials on the efficacy of daikenchuto on improving intestinal dysfunction after abdominal surgery

Lei Zhang; Yusheng Cheng; Huizi Li; Yufeng Zhou; Bo Sun; Leibo Xu

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자료유형: 학술저널

저자정보: Lei Zhang (Sun Yat-sen University) Yusheng Cheng (Sun Yat-sen University) Huizi Li (Sun Yat-Sen University) Yufeng Zhou (Sun Yat-sen University) Bo Sun (University of Hawaii at Manoa) Leibo Xu (Sun Yat-sen University)

저널정보: 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.95 No.1

발행연도: 2018.7

수록면: 7 - 15 (9page)

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Purpose: Intestinal dysfunction is one of the most common complications in patients after abdominal surgery. Daikenchuto (DKT), a traditional herbal medicine, is recently employed to improve postoperative intestinal dysfunction. The aim of this meta-analysis was to assess the efficacy of DKT in improving intestinal dysfunction after abdominal surgery.
Methods: PubMed, Embase, and the Cochrane library were systematically searched to identify randomized controlled trails (RCTs) in adult patients undergoing abdominal surgery, who were randomly distributed to administrate DKT and placebo. The primary outcomes included the time to first postoperative flatus or bowel movement. We used random-effects models to calculate summary mean differences (MDs) with 95% confidence intervals (CIs).
Results: Nine RCTs totaling 1,212 patients (618 in DKT, 594 in control group) were included in our study. Compared with control group, DKT can effectively improve postoperative intestinal dysfunction by shortening the time to first postoperative flatus (MD, -0.41; 95% confidence interval [CI], -0.66 to -0.16; P = 0.001) with significant heterogeneity (I<SUP>2</SUP> = 71%, P = 0.004), and bowel movement (MD, -0.65; 95% CI, -0.97 to -0.32; P < 0.001) without significant heterogeneity (I<SUP>2</SUP> = 40%, P = 0.14). Sensitivity analyses by indication of surgery and type of surgery yielded similar results.
Conclusion: These data provide limited evidence that DKT shows efficacy on improving intestinal dysfunction after abdominal surgery. However, the results should be interpreted cautiously, due to the heterogeneity of the studies included. Thus, the efficacy of DKT on improving postoperative intestinal dysfunction warrants further investigation.

#Dai-kenchu-to #Abdominal surgery #Intestinal dysfunction #Meta-analysis #Randomized controlled trials

참고문헌 (30)

참고문헌 신청

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[학술지(정기간행물)] - Kono T / 2015 / Complementary and synergistic therapeutic effects of compounds found in Kampo medicine: analysis of daikenchuto / Front Pharmacol 6 : 159 ~

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[학술지(정기간행물)] - Kono T / 2011 / Daikenchuto (TU-100) ameliorates colon microvascular dysfunction via endogenous adrenomedullin in Crohn's disease rat model / J Gastroenterol 46 : 1187 ~ 1196

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