T Cell-Specific Knockout of STAT3 Ameliorates Dextran Sulfate Sodium-Induced Colitis by Reducing the Inflammatory Response

Sun-Ho Kwon; Eun-Bi Seo; Song-Hee Lee; Chung-Hyun Cho; Sung Joon Kim; Sang Jeong Kim; Hang-Rae Kim; Sang-Kyu Ye

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자료유형: 학술저널

저자정보: Sun-Ho Kwon (Seoul National University College of Medicine) Eun-Bi Seo (Seoul National University College of Medicine) Song-Hee Lee (Seoul National University College of Medicine) Chung-Hyun Cho (Seoul National University College of Medicine) Sung Joon Kim (Seoul National University College of Medicine) Sang Jeong Kim (Seoul National University College of Medicine) Hang-Rae Kim (Seoul National University College of Medicine) Sang-Kyu Ye (Seoul National University College of Medicine)

저널정보: 대한면역학회 Immune Network Immune Network Vol.18 No.4

발행연도: 2018.8

수록면: 41 - 54 (14page)

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Signal transducer and activator of transcription 3 (STAT3) has a crucial role in various autoimmune disorders including, inflammatory bowel disease (IBD). Our previous study demonstrated that STAT3 activation by IL-6 in colonic epithelial cells exacerbates experimental ulcerative colitis. Activated T lymphocytes are also found in ulcerative colitis patients with intestinal inflammation, but the role of STAT3 in T cells remains elusive. To determine the STAT3 function of T cells in intestinal inflammation, we generated T cell-specific STAT3 knockout (KO) mice and used dextran sulfate sodium (DSS) to induce colitis. In this study, we demonstrated that T cell-specific STAT3 deletion alleviated DSS-induced colitis in mice, resulting in reduced histological scores and myeloperoxidase (MPO) activity. Importantly, the population of T cells in the spleen and lymph nodes was significantly decreased in the control and DSS-induced groups of STAT3 KO mice. In addition, STAT3 deficiency in T cells markedly reduced the production of interferon (IFN)-γ, IL-6, and IL-17A, whereas IL-10 secretion was increased. Collectively, the results suggest that STAT3 in T cells may be a therapeutic target in ulcerative colitis by balancing the immune response through T cell homeostasis.

#T lymphocytes #STAT3 transcription factor #DSS-induced colitis #Cytokines #Homeostasis

참고문헌 (33)

참고문헌 신청

Cader MZ / 2013 / Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation / Gut 62:1653~1664

Xu XR / 2014 / Dysregulation of mucosal immune response in pathogenesis of inflammatory bowel disease / World J Gastroenterol 20:3255~3264

McGhee JR / 2012 / Inside the mucosal immune system / PLoS Biol 10:e1001397

Harrison OJ / 2013 / Regulatory T cells and immune tolerance in the intestine / Cold Spring Harb Perspect Biol 5:a018341

Hisamatsu T / 2016 / The role of t-cell subsets in chronic inflammation in celiac disease and inflammatory bowel disease patients: More common mechanisms or more differences? / Inflamm Intest Dis 1:52~62

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